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unexplained headaches
My 32 yr old sister was diagnosed with Valley Fever 2 years ago and was treated for 6 months with Diflucan.  About 9 months ago she began having headaches.  It is now continual and sometimes incapacitating.  She has seen neurologists who can't explain it, a neurosurgeon who ruled out pseudotumor cerebri (since I have another sister with that), a D.O. for spinal manipulation, and her PCP.   She did have a LP followed by an ICP monitor for 24 hours which showed increased ICP's.   However, she does not present with photophobia, nucal rigidity, persistant nausea, fever, or back pain.  CT scans have been negative, the MRI and MRV were both negative, no medications have helped (including excedrin, narcotics, topomax, imitrex), the pain is diffuse and non-specific and more of a dull ache. Her vital signs have been WNL when tested, however no one has ever tested them during exertion when her pressures seem to be the highest.  She is literally in tears and has spent thousands of dollars trying to figure out what in the world is causing her pain.  As an ICU nurse I have suggested all the possibilities and directions I can think of.  Is there anyone out there who has any suggestions?  I was also wondering about the possibility of AAT deficiency or possibly some long term sequela from the Valley Fever.  Any thoughts?
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