Cyclophosphamide

I am currently taking oral 50mg per day of Cyclophosphamide 2 weeks on 2 weeks off. This is for a recoccurence in Dec 06 after 6 months out from first line treatment. 6 treatments of Caleyx slightly reduced my disease then i had a break with only Tamoxifan (tamoxifen) and Provera for 4 months. Then single agent carbo platin but unfortunately i had an allergic reaction on my 2nd round 2nd treatment (number 8). The carbo platin bought my numbers right down even though it was thought that i might be resistant. I am okay about taking the Cyclophosphamide as i know somebody else in a similar situation who has had a very good response. I have only just started taking it so don't yet know if it is working or not. My question is how bad are the long term side effects at this dose level. My understanding is that the dose may be increased in future. From reading info on the net it seems that it is very tough on the kidneys. I have been told to drink at least 2 litres of water per day which i am very diligent about. Can you give me anymore information about this chemo?

[Helmar]

Hi Susie... Here's a link which explains mostly what you would need to know about that drug. I had a combination last year of this and another two...called CAP..but they didn't work for me. We are all different so who knows... you could get good results. I do hope so. Like it says... drink lots of fluids..preferably water, as it's harsh on the kidneys. I hope it works well for you.
Wishing you all the best....hugs....Helen...

http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682080.html

[SusiefromOZ]

Hi Helen,

I thought i posted this to the doctors forum. But thanks anyway for the link details. How is your treatment going?

Susie

[Helmar]

Hi Susie... I'm just about finished 3 weeks off after the Topotecan. It's been like Heaven not having that lousy stuff.... go for scans tomorrow (Friday) and blood tests...see my Oncol. on Monday, so it will be interesting to see how things are. I'm feeling really well...eating like a horse...;-)...and getting out and about now that the nicer weather is here. I haven't had any scans since December last year, so it could be a real surprise package. Help. *laugh*...
I've had Tamoxifen but it didn't work for me... my numbers shot right up, but he has me on Femara now. I'm not big on the pills... just feel that we need something more substantial with this lousy disease, but we do need some breaks off the chemo though.
I hope this will work for you Susie.. or at least keep the beast under control for a while. This is one nasty disease to deal with.
Wishing you all the best....Helen..