Our 4 year old son has chronic renal failure as a result of posteriour urethral valves. his renal function is stable at present. He is also asthmatic. In the last four weeks, however, he has developed a chronic wheeze and difficulty in breathing. He has been hospitalised and given several prednisone courses as well as the usual asthma medications of Qvar and ventolin. He has had an heart echo and ultra sounds to rule out any underlying heart problem and his renal specialist is not concerned about his kidney function. He has seen a paediatric respiritory specialist whom suspected mycoplasma, however, he has tested negative to this. This morning, he is as bad as he has been over the last month and we are very concerned about him, but are at a loss about what to do next. Can you suggest any other possibilities.