The Epstein-Barr virus (EBV), also called human herpesvirus 4 (HHV-4), is a cancer-causing virus of the herpes family, which includes herpes simplex virus 1 and 2, and is one of the most common viruses in humans. Epstein-Barr virus occurs worldwide and causes infectious mononucleosis (glandular fever). There is also strong evidence that the virus has a primary role in the pathogenesis of multiple autoimmune diseases, particularly dermatomyositis, systemic lupus erythematosus, rheumatoid arthritis, Sjogren's syndrome, and multiple sclerosis. It is also known to cause several lymphoproliferative disorders and cancers, particularly Hodgkin's disease, Burkitt's lymphoma, nasopharyngeal carcinoma, and central nervous system lymphomas associated with HIV. Most people become infected with EBV and gain adaptive immunity
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