Interesting question: Since oxytocin, dopamine, lactin, serotonin, testosterone, estrogen, vasopressin, and other major sex hormones are released during sex for various reasons, could increasing the major sex hormones directly responsible for the euphoric, pleasurable feelings during an orgasm increase the pleasure felt during an orgasm?
I don't know how it would be done, but if you can think of ways that do not involve harmful drugs or any harmful method, please let me know. For example, when one masturbates after 1 day of not masturbating it does not feel "as good" as masturbating after 7 days of not masturbating (by far), and I was curious to see why that is and if there is a way to maybe trick the body into sending more of these hormones or whatever so that one could feel an orgasm that felt like they had waited a long time instead of in reality waiting just one day since the last time they experienced an orgasm. I feel like this would be an interesting experiment...let's just say people would be very interested if it turned out successful...