I am a 36 y.o. female. On Jan 21st I was 136 pounds. 6 days later I was at ER -177 pounds w/ severe abdominal bloating and constipation.I was constipated given Miralax. One week later I am in ER again @ 180 pounds,sft tissue pitted edema in right leg & calf, &l no bowel movement & ab swelling. I've been tested for Celiac and was neg..Had numerous GI tests all negative.I ws diagnosed w/ IBS-C and given Amitiza. I was in the hospital again on Friday. I looked 7 months pregnant,severe soft tissue pitted edema in my right leg.My bp was 104/64, body temp 98.2, pulse 64.They did a doppler and found no DVT, did my blood work and said it was fine.Had a cat scan and all is well.Dr. suggested that going the metabolic/ednocrine route may be the way to go.I had my thyroid tested in the early part of February and my Dr. said it was ok.Over the past 3 months I have been testing Iron Deficient Anemic with a normal retic In addition, I stopped having my period in July 07. I was told by the OB/GYN that my estodial levels were at menopausal levels but I was not menopausal.She did progestrone withdrawl at 5 mg two times with failure.She gave me Femcon FE and told me to take them to induce my period.I chose not to go that route. I started getting my period again in January 08.They are not heavy at all and last 3 days.I get tired very quickly and must take a nap when I get home to reenergize.My hands and feet are constantly cold, I have loss of appetite, and today I weight 196 pounds I have gained over 50 pounds in 4 months.Most of the weight appears to be in the thighs and abdominal area, I am also very irritable and depressed.I have shortness of breath when I get up and move around; which is not typical of me.I am sore a lot and get charlie horses in my calves in the evening time frequently.Could this be Thyroid/endocrine related? I follow a strict 1400-1600 calorie diet. Any advice or input would be greatly appreciated.