Am I hypothyroid? Do thyroid medication effects tolerate with time?

[tweaked]

I have been battling fatigue and lack of motivation for years. I regularly sleep in the afternoon despite 8-10hrs of sleep at night

[Jimlow]

Hi Tweaked,  If your thyroid panels comes back normal, I would ask for a thyroid antibodies test. You can feel hypo, if autoimmune (Hashimoto's) is going on, even before thyroid hormone levels drop on labs.
Hypo people need increased dosage from time to time because their hypo progresses, not because they develop resistance to the med. The meds are same as natural thyroid hormone, which our bodies produce life-long.
Some people do have "thyroid hormone resistance", so need very high doses for it to work but is rare.
Hope that helps.

[tweaked]

Thanks. But with the extra external hormone does whatever natural hormone production shut down and you end up in the same situation, but needing external hormone?
Or is it really the case that patients see the same beneficial effects of the same dose for years?

[tweaked]

Not that I'm doubting you, but I can't imagine actually having a magic bullet work for me, since everything has eventually failed over the years.

[meling333]

You sound like you have thyroid problems. These pills you take for ever just like your body should be producing them. Med changes through the years is normal as the thyroid can croak off more in time. You have to start out small and build up so not to through the body into shock. I was sleeping like you and never feeling rested and your other symptoms are not uncommon. Let us know what your labs are and get copies. Dont settle for feeling like ****.        Juanita