My wife has been off of Prometrium for about a month and a half, and was originally prescribed it because she had very heavy, long periods. She ended up becoming very anxious while on the medication, so her doctor told her to stop and take birth control starting on her next cycle. My wife did not take the birth control, as we were in the process of moving and she wanted to consult a doctor in our new city. Since stopping the Prometrium, we've noticed that she has the following symptoms. 1. Her periods have been intermittent. 2. Her breasts have been sore. 3. She has been unusually tired. And 4. Her nipple are very dark at the tips, almost purple, which we noticed today and is a recent development. We just moved cross-country, and it's going to take about a month before we can get her in to a doctor. We just want to make sure that nothing listed here screams "emergency."