The Sphenoid sinuses are located in the body of the sphenoid bone. This is located just behind the eyes. The inflammation of this sinus often is felt as a nagging headache behind the eyes or on the side of the head. A sinus is an air pocket within a cavity of a bone and has a narrow opening for blood vessels. These vessels are very very small and blood must pass one cell at a time. Antibiotics in the body are "cleaned up" by the liver almost faster than it can travel up into the sinus to get rid of any infection or inflammation. Because of this, antibiotics are given over a period of time instead of just a few days as with "normal" infections/inflammations. If the medication is not taken long enough, the condition may return again. Sinus drainage, or post nasal drip is an occurance that happens on a daily basis whether or not you know it is happening. As long as the drainage is clear and without odor, and doesn't taste sweet, it is considered to be "normal".