the 1st paragraph was not posted at first which partly helps answer my questions. thank you.
Since they are both not spayed or neutered and their ages are close to approaching puberty there may be a hormonal component to the problem. Your female may be going into heat early and stimulating the male. Cats can go into heat as early as 5 months of age. If this is the case than spaying and neutering will help the problem. Also, if they have gone into puberty, there is a chance that the brother could get her sister pregnant, which is ill advised.
I do not know how long you will be caring for the brother but I would keep them separated until they are spayed and neutered.
If the problem is not related to hormones than they should get along eventually, but it may take some time.