I hope you took your puppy to the vet. Wheezing can indicate pneumonia, and puppies that won't eat can become hypoglycemic.
YES.
Get her to an emergency vet right now. A tiny puppy can sicken and die extremely quickly.
See the sticky at the top of the forum page. Emergencies need to be dealt with right away. It can sometimes take a day or two for Dr. Cheng to see entries here.
Please take her to a vet right away, if you haven't already.