Symptoms Worse After Methotrexate

Jesse88

I have undifferentiated connective tissue disease and have taken Plaquenil and methotrexate for 10 months. I was recently bumped from 20 mg. oral to 25 mg. injections. After each injection my pain symptoms get worse about 4 hours later and gradually improve over the course of the week. The pain returns after my next dosage. Does anyone else experience this? Any thoughts/advice? Thanks for your help.

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Jesse88

Thank you for your response. Yes, I was taking folic acid but then was started on luecovorin, which is a stronger version. Maybe I need to take both?

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txsilver

I am taking the same meds as you but my MTX is oral. Are you on Rx strength folic acid? I know that they had to increase mine to help with the side effects. When I take MTX I feel like I have the flu for about 48 hrs and then am usually better.

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