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Low corsitol and Hashimotos

Hi there,

Any input here appreciated. My latest results have come back revealing that I have low corsitol and inflammation, although it appears that my Hashis antibodies have lowered and I'm in normal range with the FT3 and 4. I'm still feeling symptomatic and have looked into LDN as an option.

Any thoughts most welcome.


April 2015 test results:

TSH: 2.48 mIU/L Ref range (0.40-3.80) Oct 14: 3.57
FT4: 15.0 pmoL Ref range 10.0-22.0 Oct 14:14.6
FT3: 4.2 pmol/L Ref range 2.5-6.5
Anti TG Ab: 4.9 IU/mL Ref range <4.5) Oct 14: 10.3
Anti TPO Ab: 6.5 IU/mL Ref range <5.5 Oct 14: 11.5
Serum corsitol: 89 nmol/L Ref range (100-540)
23 Responses
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1530171 tn?1448129593
Hey Dani251, in a way you're lucky it is not the homozygous type, which means you have inherited 2 abnormal genes instead of just one in the
heterozygous type.
You can supplement with methyl-folate  and methyl B12, the active forms of these B vitamins in order to compensate for the hypomethylation caused by the MTHFR C677 mutation.
There are other supplements too like TMG and SAMe which lead to the same result as they are all what the call methyl donors, which facilitate methylation.
Just look up Methylation to see how important this is in the billions of biochemical reactions and processes which take place in our body.

If you need more details on this, I'm quite familiar with this mutation.

Cheers,
Niko
Helpful - 0
Avatar universal
I was going to wait until July (as had a consult with doctor over phone and she's opted to wait to see if progesterone levels up with corsitol improvement- but another one of the tests reveal  I have the heterozygous MTHFR (c677T) gene. Just reading up on this today and trying to figure out what it means for me. It seems rather common so I'm trying to be practical in my approach.
I don't know if that's something you're familiar with?
Thank you and hope youre really well! :)
Helpful - 0
1530171 tn?1448129593
Hey Dani,
I don't know about the progesterone cream,in Australia.
Would you please ask your Pharmacist?
It will be very useful to know in what strength(s) it is available also.
That way, I can try guide you better.

The endocrine, adrenal and thyroid glands have to do with the entire body,
so it's natural that you're feeling this way.
Once you get these under control-easier said than done,lol!-you'll be like a new person!

Cheers,
Niko
Helpful - 0
Avatar universal
haha! Ah don't worry, it's better to be across everything I guess! :)

I'll ask her, thank you! I'm interested in the progesterone cream! I might have known there was a link. It seems all my systems have been out of whack.

Do I need a prescription for the cream? I'll try to arrange an earlier appointment to follow up on all of this,

Thanks so much for your help!
Helpful - 0
1530171 tn?1448129593
Hey Dani, I'm so glad you're feeling better.

Well, you bet your sweet peas, your low progesterone is related!
Just google:
"Images for hormone production pathway" and open  the top right chart
which will be the easiest to read.

You will see that Progesterone is necessary for converting to cortisol ,
as there's no other source for cortisol.

But it seems that in your case, Progesterone may be depleted due to the increased demand for cortisol by your stressed adrenals!

Yikes! I just knew this was gonna be an issue for you from before.

Now, this does not stop there. You will have another issue to deal with at the same time. a heightened estrogenic effect, due to an estrogen/progesterone imbalance called estrogen dominance.

So, it looks that you have to fix both, the stressed adrenals / low cortisol AND the estrogen dominance/ low progesterone, as they're all interlinked.

For now, I suggest you look into improving your progesterone levels to offset the estrogen.
You can use a natural (bio-identical) progesterone cream, which I believe is a superior way to supplement.
Using the cream properly is not an exact science, as frequency, site of application, strength, time of the day applied, etc. are important variables to be worked out.
If you decide for this, let me know and I can try to help you optimize the
process.

I think it wouldn't be unreasonable to press for this, instead of waiting till July. But please have your cortisol levels monitored periodically, in light of
the low progesterone and the potential cortisol lowering effects of some of your current treatments.

Hey, I didn't mean to spoil it for you, but on the other hand, I'm happy you're feeling the shift in energy!

Oh, at the same time you may ask your doctor what she thinks about
you taking the smallest dose of glandulars, as a trial.

Cheers,
Niko

Helpful - 0
Avatar universal
Indeed! We are far apart, although you have helped me a great deal, and I thank you!
I will make up the magnesium spray, as you've suggested. No plans to bring the LDS up any higher. Feeling better now as it is so will keep it slow and steady.
With the corsitol issue, I'm not sure if I should wait until my next blood test in July to see how I'm doing, or ask for more intervention at this point. Might just let things settle down and see if the improvement continues. If you think I should be pressing for anything else, though, please let me know (glandulars?)
I have found out my progesterone levels are also low - not sure if that's related but I will need to figure out what's going on there, too!
My body is keeping me busy! But I'm on the mend - there's a definite shift in energy happening - and I'm grateful for it! :)
D
Helpful - 0
1530171 tn?1448129593
Cold extremities, hmm. Constriction of the capillaries will cause Reynaud's Disease-look it up-
and at night (or when the barometric pressure is going down due to worsening weather)  symptoms are worse, due to the decline in cortisol.

Blastocytosis is a parasitic protozoan infectious condition which targets mainly the G/I system.
Coconut oil is a good remedy for this infection, since it has both anti-protozoan and anti-parasitic action (among it many other medicinal properties)

You must be aware that you are more vulnerable to parasitic, viral and bacterial infections when your cortisol levels are low, as I already mentioned.
Cortisol is an immune system regulator.
The intestinal pathogen screen is routinely ordered when cortisol levels are low, in Naturopathic Medicine, following a positive adrenal stress profile.

Forgive me for repeating certain things, but because of the large amount of information, some of the important facts can easily get missed.

She wants your Magnesium levels up, hmm; it's going to take years perhaps. At an average efficiency rate of only 3-4% of oral magnesium,
and this is not taking into consideration any underlying issues interfering with absorption and assimilation, it seems like an uphill battle.

Look into Transdermal Marnesium Oil treatments, by far the most efficient and safest (oral magnesium is highly laxative) method to supplement.
You can make your own by using Magnesium Chloride flakes and hot water, 50/50, wait trill cool and then put in a spray bottle and spray on your body -avoid sensitive areas-  leave on for 30 minutes to absorb and then shower.
Every day for therapeutic purposes for about 3-4 weeks and after that every other day.
Dilute further if you feel it's too strong at first, but your body will get used to the 50/50 solution fast.

The glandulars I referred to, had to with adrenals and cortisol, just to be clear on that.

I would like to see you stay on the 1.5mg starting LDN dose until your cortisol levels improve, as a precaution.

The subconscious is more or less in charge of YOU, so when you can
access the subconscious and make changes, you assume control of many aspects of your life.
Too bad we're like 10000 miles apart, I could facilitate many things for you.

Have a good day,
Niko

Helpful - 0
Avatar universal
Sorry, I should have mentioned - natural thyroid was not discussed...and my LDN dose is 1.5mg
Helpful - 0
Avatar universal
You sound like you have a great system! The sub-conscious is an interesting area indeed and probably has a lot to do with everything!

I've just been a busy bee lately, with a rather hectic schedule of medications to take every day. My doc discovered I have a blastocystosis infection and has put me on paramomycin for 10 days, as well as probiotics and a herbal intestinal powder formula. It's all very expensive!

I have been getting very cold hands and feet these last few nights, and I'm not sure what that's all about. My doc is now away on holiday so it may have to wait to be investigated. However my T3 starting dose is 10mg. Could this be too low?

The corsitol issue seems to be on the backburner with the doc, but I'll see how I go. She wants me to get my magnesium up and continue this course...

With the adrenotone - I'm a tall, big boned person so I've been feeling fine with 3. But I feel like I'm popping a lot of pills!

:)
Helpful - 0
1530171 tn?1448129593
Standard Naturopathic/Holistic approach.
The adrenal support ( Adrenotone ?) is well-formulated, except I have some reservations with the withania ( winter cherry or  Ashwagandha), since it may reduce  cortisol levels. It's  used as an “adaptogen” to help the body deal with daily stress.
Should the LDN  therapy cause cortisol lowering effects, since your cortisol levels reported were below range, it could potentially leave you with inadequate cortisol to function well. I encourage you to discuss this with
your integrative health doctor.
My suggestion would be to keep a very close eye on cortisol levels, by frequent testing, so a trend can be established. This way a downward spiral can be easily prevented .
Personally I favor 4 x saliva cortisol testing.
Are you on 3 tablets daily? If you're a petite gal, I suggest you take only 2.

Did your doctor discuss Glandulars (natural) with you?
The principle of Glandulars was known since ancient times that taking the organ or gland from animals can strengthen and support the function of that organ or gland in humans. I have the feeling that a small dose trial, may be of benefit.
IDK, I might be missing some information, regarding your cortisol levels.

Oh, I usually have a very easy time to settle in and adjust to anything.
My hypnosis and therapy background come in handy, when it comes to
keeping things balanced. I do a lot of experimenting with my sub-conscious mind, where I tend to  stretch the boundaries. So far I've tamed the effects of jet lag, increased my metabolic rate  and reduced the amount of sleep
that I need in a safe and sustained manner. Love this stuff!

Cheers!
Niko

Helpful - 0
Avatar universal
Thanks Niko,

I'll ask her about the tests you mention, for sure. That's really helpful.
Right now, my regime looks like this:

2x 1 g fish oils (medically graded) doctor said many brands contain unacceptable levels of mercury, despite labeling.

An adrenal booster 3x day comprising:
• Withania somnifera root dry (Winter Cherry) 3.8g
• Eleutherococcus senticosus root dry (Siberian Ginseng) 2.8g
• Rhodiola roses root dry (golden root) 1.0g
• Glycyrrhiza glabra, root dry (Korean Ginseng)
• Tyosine 500mg
LDN – 1.5m nightly
7 keto DHEA 1xdaily in morning (after a month increase to 2xdaily)
T3 (have to check dosage!) in morning also on empty stomach
Vitamin D
Vitamin C
Iron (ferro-grad - dried ferrous sulfate 325mg and sodium ascorbate 562.4mg)
Selenium 150mcg
No vitamin B until blood tests come back revealing which type I need

Also having a GI pathogen test.

Feeling good about taking positive action. I hope you're settling in well after your trip!

D
Helpful - 0
1530171 tn?1448129593
You're welcome!

Nice! You are in good hands.

FYI: Gluten Intolerance and Hashimoto's.
Look into Gliadin test (urine), by Cyrex labs. They test 12 forms-not just the alpha ordered by most doctors- of gliadins regarding gluten intolerance (not necessarily digestive).
Now they can also test which part of the body is affected.
Most hypothyroid sufferers have gluten intolerance and don't even know it!
The gluten molecules-mainly from gmo grains- resemble the TPO molecules(Thyroid Peroxidase - an enzyme necessary for the signalling Thyroid hormone production - you know this already-)  and thus the immune system in its response against gluten, attacks the TPO in the Thyroid also!  You have made  great choices so far!

Cheers!
Niko

Helpful - 0
Avatar universal
Thank you! I'm so delighted to have found a doctor like her - she genuinely cares, wants to help and is looking at the issue holistically. :) and thank you for taking time to respond when you're on the fly!
I'll have to check Re. the T3 dose, as she faxed the prescription away and I'll have it by the end of the week.
I forgot to mention that she also ordered a intestinal pathogen test, just to rule it out. I'll bear in mind the corsitol issue - certainly don't want to aggravate it.
I must admit, it's only been about 5 days gluten free and coffee free, but I feel better already.
I'll post the proper list of med, vits and dosages tomorrow.
Thanks again :)
Helpful - 0
Avatar universal
Thank you! I'm so delighted to have found a doctor like her - she genuinely cares, wants to help and is looking at the issue holistically. :) and thank you for taking time to respond when you're on the fly!
I'll have to check Re. the T3 dose, as she faxed the prescription away and I'll have it by the end of the week.
I forgot to mention that she also ordered a intestinal pathogen test, just to rule it out. I'll bear in mind the corsitol issue - certainly don't want to aggravate it.
I must admit, it's only been about 5 days gluten free and coffee free, but I feel better already.
I'll post the proper list of med, vits and dosages tomorrow.
Thanks again :)
Helpful - 0
1530171 tn?1448129593
Oh I also meant to ask you about the LDN -I'm rushing I,lol!- due to its possible anti-cortisol effects are you on the recommended standard dose or less?

You see, it will likely have mixed results, so my approach would be a starting dose of 1/20th of the standard Naltrexone dose, instead of 1/10th, but not before the a 24 Hour saliva cortisol test (adrenal stress profile- 4 x cortisol, 2 DHEA averaged) ) is done., as I mentioned originally.

If cortisol levels come back low, I would delay the LDN, till cortisol goes up

Also I would also recommend a "GI Pathogen Screen",  especially if your cortisol levels come back very low.
Cortisol regulates the immune cells in our gut so when cortisol is depleted those cells become dysregulated, making us more susceptible to pathogens like bacteria, yeast, and parasites.

Helpful - 0
1530171 tn?1448129593
Dani, your new doctor is a gem!
I'm really impressed with her prescribing LDN and T3 only.
(I'm very familiar with LDN)
I had started feeling bad for all my Aussie friends who had problems with their health, mainly b'cause of how doctors there usually treat patients.


What is your starting dose of T3?

And you're very welcome. Glad to see you're getting on with receiving
some proper treatment now.

I'll post again later with a couple suggestions for AF. Just came back from a trip and have lots to do.

Cheers,
Niko
Helpful - 0
Avatar universal
Thanks Niko,
Yes, what a high score! ;)
I'm feeling very hopeful today because I've been to see a new integrative health doctor and she's done the following:
Prescribed me with LDN and T3 only as well as helping me address my vitamin and mineral intake.
She's ordered new bloods too and will monitor closely.
I'm going to make the switch, continue to be gluten free and work hard to repair my adrenals!
I really appreciate your help and would be interested in your thoughts!
Helpful - 0
Avatar universal
Thanks Niko,
Yes, what a night score! ;)
I'm feeling very hopeful today because I've been to see a new integrative health doctor and she's done the following:
Prescribed me with LDN and T3 only as well as helping me address my vitamin and mineral intake.
She's ordered new bloods too and will monitor closely.
I'm going to make the switch, continue to be gluten free and work hard to repair my adrenals!
I really appreciate your help and would be interested in your thoughts!
Helpful - 0
1530171 tn?1448129593
Hey Dani, for some reason that's the score I seen for you from the start.
Don't ask me why or how.

In adrenal fatigue, thyroxine (T4) is perhaps converting to Reverse T3, further lowering triiodothyronine (T3).

The lower back soreness could actually might not be related to the kidneys, but the stressed adrenal glands (or both!).
The adrenal glands are directly above the kidneys.

It's a step in the right direction to cut out gluten and alcohol.
You absolutely need to optimize your nutritional intake and conserve energy as much as possible. It is one of the keys for AF recovery.
.
What are the chances of your prescribing doctor to prescribe Cytomel or its equivalent (T3 only) instead of thyroxine and take just the starting dose at first ?

I'll be away for a few days, but meanwhile you can post with your comments and concerns.

Cheers,
Niko
Helpful - 0
Avatar universal
My total score is 18! I've just switched to taking my throxine at night too, and I don't know if this is the reason I'm waking up in the night absolutely parched and needing to use the bathroom.
I've just cut out all gluten and alcohol too, and I don't use sugar often.
I just feel lousy. I have lower back soreness that may be my kidneys.
Just not feeling good!
Thanks for all your help
Helpful - 0
1530171 tn?1448129593
Hmm, AF is very  challenging to treat.

I don't recommend you approach this completely on your own.
But I'll give you some basics.

First you need to be assessed.

On your own you can do a screening questionnaire.


Adrenal Questionnaire  

Read each question carefully, and record the number next to a question if it applies to you.
When you finish, add up the numbers you have recorded.


Do you experience fatigue? 3


Do you have allergies? 3


Do you have asthma? 3


Do you have recurrent infections? 3


Are you under severe emotional stress? 3


Do you suffer from chronic pain or physical stress? 3


Do you have low blood pressure? 2


Do you have a low pulse rate (<70/min with no exercise)? 2


Do you feel faint when you rise quickly? 2


Do you experience depressed moods? 2


Do you experience joint pain? 2


Do you have muscle pain? 2


Do you have low libido? 2


Do you have hair loss? 2


Do you have anxiety attacks? 2


TOTAL SCORE _______  

Less than 7 adrenal fatigue unlikely
7-12  adrenal fatigue possible
Over 12  likely.

Note: The points for each answer are set.
There's no intermediate. Full points for affirmative and zero points for negative answers

Let me know your results and  we'll go from there.

Cheers,
Niko


Helpful - 0
Avatar universal
Thank you for taking the time to respond. Certainly, I've a lot to think about! I'll do some further research based on the points you mention. If you have any comments on treatment for this adrenal fatigue, I'd be really interested to hear them!
Best wishes
Helpful - 0
1530171 tn?1448129593
Hi  Dani.
Your low serum cortisol is of  greater concern than your below range TG and TPO.
The reason is that there's suspicion of hypoadrenalism or as commonly known as Adrenal Fatigue-but not an "established" conventional medical diagnosis- which is notoriously difficult to treat through... conventional doctors, naturally.

For starters you really need to know your 24 hour cortisol (cortisol follows
the circadian rhythm). My suggestion is a 4 x cortisol  (adrenal
stress profile) and 2 averaged DHEA-S- saliva test.

The situation is complicated when you have Hashimoto's and Adrenal Fatigue. The stressed adrenals down-regulate thyroid function for recovery
something that cannot happen while on continued thyroid medication
for hypothyroidism!
In the end, should you indeed have Adrenal Fatigue,if not properly addressed soon, it will likely progress to the next stage, rendering any recovery efforts even more difficult.
it can be very hard to dig yourself out of that hole, and it also requires a lot of commitment and focus and time.

I  hope that you don't have Adrenal Fatigue- which raises another question,how would you really know?
Because to put it bluntly, conventional doctors will not consider adrenal
fatigue till it becomes a true adrenal crisis in stage 4, just in the brink of adrenal failure. Unfortunately full recovery is not possible at that point.


I urge you to find a holistic and open-minded Doctor who has experience in Holistic Endocrinology and willing to treat you properly without being bound by the rules and limitations of Conventional Endocrinology.

Meanwhile, try to educate yourself as much as possible in this field.
It will help you become a better patient and probably improve your prognosis.
If you have any questions please let me know.

Oh, BTW LDN may have anti-cortisol effects, so please put this idea on the "back burner" for now, even if you may have heard of some people with Hashi's who experienced  positive results.

Best wishes.
Niko





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