I have 2 questions: I'm Bipolar and I've been on medication for nearly 9 years. The one medication that I've been on for the duration of this period is Effexor XR. My first question is: Are there any known long-term side-efffects, particularly regarding inertia? Because I have absolutely no motivation; it's been like this for years. I come from a family of extremely motivated people, and even when I'm feeling great I'm still totally unmotivated, and often tired. I'd realy like to get off my meds, but since effexor has such horrible withdrawl symptoms I know this is virtually impossible without professional assistance. Which brings me to my second question: Has the supplement Sam-e been effective in treating bipolar disorder? Would it be possible for me to supplement all of my medication with Sam-e?