I've been on and off lithium past 8 yrs now.then 1st 2 yrs i went toxicity i was in icu 4 days.1.5 being serve toxic i was 3 double..so they kept trying to put me on a med.wasn't anything.so they put me back on lithium..been on it since.it helps me.i got my labs the other day, btw i,m on 1050mgs,the lab was good on the lithium 1.0 but my kidney lab showed my creatine 1.5 reference is 0.6-1.2 this brought my GFR to 48.77 normal is greater than 60..this is stage 3 CKD..just 3 months ago it was perfect,,i had them redo this test.this time i made sure i had very little protein and was very hydrated. The test on the creatine was 1.2 GFR 60 was on but still on the top end. i was borned 1 kidney. they say lithium will hurt the kidneys after long time on it.but what about a man thats only had 1 kidney since birth?? also the thyroid can have issues from lithium.......so i,m weening myself off started 4 days ago. Going slower.my pdoc doesn't know it.he would try to stop me..he doesn't understand my 1 kidney, no body would unless they been doing lithium and only having 1 kidney. I know a few people on 1800mgs of this there levels still at 1.0-1.1..what would you do in this case...oh bipolar mixed,ocd meds lithium lamctail 400mgs Xanax 6mgs.. THANKS