Please help need answers

[giules90]

I really need some kind of answer please, I have now had 4 SPEP blood tests each time my levels of alpha 2 and beta 1 have increased. The last one now shows alpha 1 also increased. These are the latest results with ranges;

total protein           81       (65-85)
albumin                 50       (38-50)
alpha 1 globulins   4        (2.1-3.5)
alpha 2 globulins   10.5   (5.1-8.5)
Beta 1 globulins     6.2    (3.4-5.2)

The rest are in range, I put total protein in as it is also rising though still in range. Comments say oligoclonal banding in the gamma region. My doctor was a bit concerned by the last test and called me in but between me seeing her she had spoken to the rheumatologist who dx'd me with fibro over a year ago and she told her to ignore it! The rheumy shares rooms with a heamatologist whom she is supposed to be talking to about it but I can see this is just going to be ignored. I am a bit concerned at this as there must be a reason for these increases?
As well as fibro I also have hashimoto's (autoimmune thyroiditis), IBS, lactose intolerant and am going in for hip arthroscopy in early Feb.
Does anyone know if any of these could be causing my off levels? I am so tired all the time I have to push myself to get going and the constant pain I have is wearing me down. Can anyone please give some insight? I would be really grateful. Thanks

[giules90]

Just an update
So I went to see my doc, she had spoken to the haematologist who said not concerned with my test results. Rhuemy wants me to repeat all the autoimmune blood tests I had done a year ago. Ok fine I thought and as I am due for hip surgery in a few weeks i didn't push this matter. But last week i got a letter from my doc (asked for by the rheumy) with a request for a protein electophoresis urine test (Bence Jones Protein). Now I know what this test is looking for and is primarily Multiple Myeloma. So how can they say to dismiss the blood tests if they are now wanting to check for this? It doesn't make sense. Anybody have any ideas as to what they are doing? Thanks for any replies.

[giules90]

Wow thank you for your input. I am low in Vit D and also B12. My doc is having me checked regularly for this, particularly B12 as she says I may not be absorbing it properly. I guess with the 2 that would account for the pain and fatigue?. I have been tested (a year ago) for RA, lupus and sjogrens plus a myriad of other blood tests and more recently for celiac and liver issues. I have 2 hemangiomas.
I'm not sure from your lists that all 3 abnormalities (although slight) tie in together, or maybe it is the hashimoto's/fibro. I have been going through a lengthy flare now for over a month.
I will be speaking to my doc today about the referral to a haematologist and think I will ask to see one anyway regardless of what the rheumy says. I would prefer a definate answer that it is down to my hashimoto's rather than a probably is.
Can I please ask for your opinion? Or am I overthinking it?
Thanks

[Red_Star]

Albumin levels may be elevated in:

Dehydration
Congestive heart failure
Poor protein utilization
Glucocorticoid excess (medications with cortisone effect, the adrenal gland overproducing cortisol, or a tumour that produces extra cortisol like compounds)

Possible causes of high blood protein include:

A bone marrow condition
Amyloidosis
Dehydration (which may make blood proteins appear falsely elevated)
HIV/AIDS
Monoclonal gammopathy of undetermined significance
Multiple myeloma

Increased alpha-1 globulin proteins may be due to:

Acute inflammatory disease
Chronic inflammatory disease (eg: rheumatoid arthritis, SLE)
Cancer

Increased alpha-2 globulin proteins may indicate:

Acute inflammation
Chronic inflammation
Nephrotic syndrome

Increased beta globulin proteins may indicate:

High cholesterol
Iron deficiency anaemia
Estrogen therapy

Specific conditions that show oligoclonal bands include:

Multiple sclerosis
Lyme Disease
Devic's disease
Systemic lupus erythematosus (SLE)
Neurosarcoidosis
Subacute sclerosing panencephalitis
Subarachnoid haemorrhage
Syphilis
Primary central nervous system lymphoma
Sjögren's Syndrome
Guillain-Barre Syndrome

Vitamin D deficiency is very common with autoimmune diseases. In one study, 93% with bone and muscle pain were found to be deficient in vitamin D. The vitamin D council recommended vitamin D levels between 50 - 80ng/mL or 125 - 200nmol/L.

Diseases that have been associated with Hashimoto's Thyroiditis includes:

Rare lymphomas of the thyroid gland
Primary pulmonary hypertension

Autoimmune disorders that occur with increased frequency with Hashimoto's Thyroiditis include:

Insulin-dependent diabetes mellitus
Myasthenia gravis
Celiac disease
Pernicious anaemia
Vitiligo
Rheumatoid arthritis
Systemic lupus erythematosus (SLE)
Scleroderma
Primary biliary cirrhosis
Dermatitis herpetiformis
Sjogren's syndrome