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Grade 2 Mast Cell Tumor

My dog had a Mast Cell Tumor removed from the top of his right ear with margins measuring 0.50 CM - 0.75 CM and deep margin is about 0.25cm. The pathology report showed it was a grade 2 mast cell tumor with mast cells in the dermis and superficial subcutis. There was mild nuclear pleomorphism and the mitotic index is low less than 1 per 40X high power fields.Sclerious and eosinophilic inflammation are also present. The overlying epidermis is hyperplastic and elevated. The above surgical margins are clean and there was no evidence of angiolymphatic invasion. What are the chances of the mast cell tumor metastasising? Is radiation treatment the way to go?  How long will a mast cell tumor take to return if it does?
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803451 tn?1390083422
A related discussion, Mast Cell Tumor was started.
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931217 tn?1283481335
You might find this previous MedHelp post and followup useful:


Best regards,

Arnold L. Goldman DVM, MS
MedHelp & PDOC
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In most cases Mast Cell tumors once removed are fine. They may come back, but if they do, it is locally as they do not metastasize or spread through the body.

Although each veterinarian has his or her own protocols as far as therapy for mast Cell Tumors, in my experience, once removed, most dogs, 99%, plus are fine.

Because the margins are clean, your vet did a good job and chances of recurrence are possible but not highly probable.

We recommend altering diet to either home-made or organic and boost our canine patients internal immunity to help prevent recurrences. We has had very good results using with an all-natural vitamin supplement, called Paaws, which is also patented for dogs.
We have not had to resort to chemo or radiation for our canine patients with this diagnosis.

Because your dog is young, consideration of natural, holistic therapies would be well warranted in my opinion and help him to enjoy many more happy, healthy years with you.

I hope this information is somewhat helpful and would be glad to discuss this with you further.

Best Wishes
Dr. Carol Osborne, DVM
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