Although I have low LDL without statin therapy, I started a statin because of significant family history. Recent evidence seems to point to very low LDL (<70) being even better than low LDL (<100). More recently JUPITOR showed that <50 was better than <70. However, what is particularly interesting is that statins seem to reduce cardiovascular events through mechanisms other than LDL lowering. Such mechanisms may be anti-thrombotic, anti-inflammatory, and anti-oxidant. Do we understand what dose is necessary to get these non-LDL lowering benefits? For example, I take 5mg of Lipitor daily. The reason for the dose being so low is that my LDL was low to begin with (91) and I am very sensitive to it (i.e., just 10mg brought it down by 47% to 48).