I was on Effexor 75 for x 8 years, i went off in Dec and it took me about 3 weeks to wean myself off. Felt great, not so tired. Felt that i didn't need it anymore and was so happy. Then in May i started feeling a bit unsettled, frazzled. In June i felt down and my thought process were working over time, anxiety was coming back. In July i was startled about something that happened in my life and presto, depression and anxiety hit like a ton of bricks. i sunk into a dark place, felt like my world was falling apart. I lost 15 pounds in a matter of a week because my anxiety was so high. So my question is that i am not sure if somehow the drug stayed in my body till about 4 months later when i started to feel the effects of Effexor wearing off or if infact my depression came back.