What exactly is the action of Zoloft and Lexipro as apposed to Wellbutrin? What do they affect? I took Zoloft for almost a year and had blurry vision, shaking all over, and increased confusion, and memory loss. I finally asked my doctor to change from Zoloft to Lexipro, and have taken it for 2 months. The doctor was wise enough to make the transition slowly, but I felt suicidal the first 3 weeks on the Lexipro, and became obsessed with eating food that I know are not healthy...and couldn't stop. While on the Zoloft I lost 30 pounds-as I just didn't have any desire for eating all the time. On Lexipro, I gained 20 pounds back, in 2 months. Today, I asked my doctor if there was an anti-depressant that would help my depression, and not make me obsessed with food, and suggested Wellbutrin instead. She said it had a different kind of action than Lexipro and Zoloft-and something about them being seratonin reuptake inhibitors and Wellbutrin had a different action and worked on dopamine (if I am remembering correctly). What exactly do these terms mean-what do each of these antidepressants do to the body. I add that about 9 years ago, a doctor tried prozac on me, and stopped it abruptly, as it was giving me tremors, and I became suicidal. This doctor replaced that with paxil, which made me feel like I was on cloud 9, but gave me the shakes again. So, the doctor put me on effexor-all antidepressants had worse symptoms than I started with. I read once that if you have shakey reactions to these types, you may have Parkinsons, which runs in my family. As it was taking a lot of time from work to go to the doctors, and the neurologist I saw said it sounded like I had more problems with medications than I started with, and by the test that had been taken on me-an EEG that was suspicious for epilepsy, I decided to try the ketogenic diet that I had just heard about, and tried to help myself without doctors, and reading about what may help. I spent quite a few years trying to manage my depression 5-htp with (I had tried SAM-E, and started the shakes again) and St. Johns Wort. It came to the point that my body seemed to override and become immune to any treatment I tried for controlling the pain and urgency, and it seemed I just needed more and more. I have interstitial cystitis, and this health problem leaves me in chronic pain, and always on pain killers. Anti-depressants are commonly taken for people to cope with chronic pain, combined with the pain killers, slow my abilities to pass a stool, and even though I still feel the extreme pain of the bladder, and the urgency, the anti-spasmodic drugs like pyridium and urelle and detrol LA left me completely unable to go to the bathroom (also with an extremely dry mouth). For the dysfunction of the bladder, my urologist gave me cyclobenzaprine to help me relax when I tried to use the restroom, and said it would be acceptable to stop taking the detrol LA since by this time, I was disabled and staying at home, close to a bathroom, since my usual amount of urinating was around 60 times a day, waking every hour, if I was even able to sleep. I am now taking clonazepam to sleep, as well as something called knock out (a mix of melatonin, theanine and other sleep aid herbs) which helps me fall to sleep. The anti-depressants are a key point in my pain and depression managment. Oh-I forgot to mention that for the cystitis, I take other medicines that my doctor recommended-amatryptaline and benedryl. When I can't get control of the pain, my husband catheters lidocaine, or marcaine, and I have a TENS machine. Each of the anti-depressants gave me different and additional problems, but since the loss of my job left me in a physical, emotional, and mental breakdown (I was the housepayment) I didn't want to stop taking them, as they kept me from crying all the time. I was completely exhausted on most of them. I am not as upset now that I have been approved for social security and will be able to pay my bills, but, I would like to know what each of the anti-depressants do, and what is the main function on the brain. Answers and suggestions appreciated. Peaceful1