I have been on three SSRI's in my life. I was put on Zoloft when i was 16 but was only on it for about ten days, and was then hospitalized for meth abuse, where i was taken off the zoloft. I was abusing meth while on the zoloft so i didn't think much of it when my lips swelled up and got rock hard. I figured it was because i was using zoloft and meth at the same time. About a year later i was put on effexor XR, and remained taking it for about 18 months. The same lip swelling happened, but never got rock hard like before. i figured it was just extremely chapped lips. they would swell up often, at least a couple times a month and would remain swollen for a week at the most. I eventually was taken off effexor, and about a year after that i started taking wellbutrin. sure enough, after nine days of being on the wellbutrin, my lips swelled up again, which they hadn't done since i was on effexor. i am not on the wellbutrin anymore, but am still wondering if the SSRI's is what caused that reaction.