Sorry for the delay, I must have missed your post.
SNRIs or SSNRIs are Selective Serotonin-Norepinephrine reuptake inhibitor. The reuptake inhibition of norepineprhine gives them their stimulating proprieties. For a better understanding of what is norepinephrine I can call it noradrenaline. Now you should understand why it is stimulating.
The monoamine transporters are, to make it simple, are simply what is transporting the neurotransmitters. So, serotonin (SERT), dopamine (DAT) and norepinephrine (NET).
If she have trouble sleeping she can talk to her doctor about the tetracyclic mirtazapine and should avoid the SNRIs because they are stimulating. Since you mentioned the insomnia I can understand why she was prescribed Seroquel, a lot of doctors will use it for both depression and insomnia. If she have trouble with both insomnia and lethargy she can try adding Wellbutrin with her doctor to take during the daytime since mirtazapine is taken before bedtime. There are many options, just letting you know my opinions.
M4
Um sorry what are SNRI's ? they sound like what she needs.! Also transporters ??? I am a bit lost ,sorry this is not in my area of expertise, it sounds fascinating.
Wow you certainly know your meds.Thankyou so much I will print this and pass it on.
No my friend is no way bipolar this is what I was worried about.She has trouble sleeping but I thought that there would be safer alternative as often depression and insomnia go hand in hand,and no way is she psychotic.This is what her doctor prescribed her and yes I would have thought Prozac or the like.
She is in that black hole of hell and needs to be pulled out of it like I was. This is a short poem I wrote when I was in there.
You like dark enter my mind.Great sadness strong to survive.
True love no more just distrust and discust stand at my door.
My ex walked out after 40yrs.
Thankyou sweet man.
Maddie you are one lovely lady.I am on 300mg a day been on for 12yrs ever since my daughter had her awful accident,had to it gave me strength for all those bad yrs that followed.
I would have never got through without my three big fury bundles of joy.
Thankyou Anne.
Hi, nice to see you on this site too. I did not realise you had depression. I am on Effexor 150mg, and it suits me very well. Yes the withdrawl is awful. I went off Effexor for a year, but the depression did come back, and I am on it again. Will never stop. Had depressio9n for 20 years.
I first got a dog to help me with depression, as I had to take dog out. You are so helpful on the dog forum, bless you.
Sorry don't know about Seroquel, just thought I would say hi to you.
Anne
Please note that I don't now your friend and his medical history and if the treatment is really for depression or something else with depression like bi-polar, in the case the patient is bi-polar it is true that Seroquel is a wiser choice.
Generally you don't start treating someone with depression with an antagonist, in that case, the atypical antipsychotic Seroquel. You will generally try the softer SSRIs out there first like Zoloft, Prozac which have their success history. If they fail you generally move on to try a SNRI depending on what the patient is complaning or add a DNRI like Wellbutrin. SNRIs are helpful in patients with lethargy and low motivation. If it fails then now you can move to the tetracyclic or atypical kind of antidepressant like mirtazapine and try antagonizing the receptors you think are involved in the depression.
From a neurobiological point-of-view, depression is complicated and it often involve more than one monoamine transporter. Monoamine tranporters are serotonin, dopamine and norepinephrine. Some will have success with all 3 monoamine transporters taken care off. Another kind of depression is a psychological depression with no evidence of neurobiological disruption in the monoamine transporters. those kind of depression are usually treated successfully with counseling and respond well to placebos in clinical studies.
Please note that your friend must consult his doctor before making any decision regarding the medications.
M4