Wellbutrin change in effectiveness

[Sem1retired]

I've taken welbutrin xl 300 mg for years. This year I gained over 30 lbs and my depression has increased. Recently my depression has really increased. My psyciatrist increased dosage to 450 mg about 3weeks ago. I am very depressed now. Go to bed (my only escape) and don't care if I ever wake up again. I have no drive. Nothing interests or motivates me.   What do I do? It is Sun. I don't think I should go to emergency. I have to work 11hrs tomorrow starting 7am. I am having a difficult time. I have not taken today's dose yet and I feel less foggy.

[Paxiled]

Don't quit these meds abruptly -- you need to taper off of them slowly.  But it does sound like this med isn't working for you anymore.  Given the reputation this drug has for being highly stimulating and therefore the best drug for not gaining weight, the fact you're gaining a lot is another indication it isn't working.  I would keep working -- keep your routine, don't start isolating yourself -- but have a talk with your psychiatrist about this.  If you don't get an answer that you think sounds like it make sense, find a new psychiatrist.  None of us can be sure about this, but unless there's been an event that has happened that might be overwhelming the drug, all things being equal, it does seem to have pooped out.

[AnxiousNoMore]

There are lots of other meds out there to switch to, so does your psychiatrist know you are feeling foggy at the higher dose?