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antidepressants

How do you stop taking nortrilen?.  Do you gradually come off or just stop?.  I am on them as i had muscle deterioration which these pills seem to help but after 2 years was advised to come off them as they cld damage my liver and kidneys.  I have tried twice but then my muscles ache to much. Is it the lesser of two evils.  The doctors say it is my choice and they cannot help me or advise me.  Help..  Am i to suffer aching muscles or risk damaging my liver and kidneys or IS there an alternative.  Please advise. Just to let you know i have collitis so have to be careful what drugs i take.  Am also on warfarin for life.  I am 50 years old.  Thank you.  
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Avatar universal
Oh you mean Nortriplilyne?

Sorry, never heard it called by the name nortrilen before. That must be what they call it in Europe.

I took Nortrip at 75Mgs a day for about 16 months. Great antidepressant. It gave me 14 months of complete remission from the severe symptoms of my Depression and anxiety.

(Was hoping to get at least two years from it before it pooped out on me)

Oh well, Now days I'm happy for any relief, even if just temporary.

I can tell you how I stopped taking it, but it may not apply to your situation. This is why:
You see, Iv'e had to take AD medication of some sort for the last 16 years (when I was diagnosed with Severe Uni-polar depression)

Over the last 8 years or so, I have had to change medications at least a dozen times, simply because I have developed what's refered to as Refractory Depression. It basically means that my condition has grown very resistant to Antidepressant medication therapy.

Thus I find myself having to change meds every 18 to 24 months in order to get a response.

I am currently in the process of tapering off Nortrip and simultainiously ramping up (my new med) Remeron.

The reason I say my experience with stopping Nortrip may differ from yours is because I am replacing it with another AD drug. Doing this often makes "withdrawl symptoms" much less severe.

What I can tell you is that this is my first day of ending my taper off of Nortrip and my withdrawl symptoms have not been too bad.

I lowered by 25Mgs a week for three weeks.

The good news I can tell you is that My withdrawl symptoms when I tapered off Effexor and Lexapro were MUCH worse than with the Nortrip.

Even with a slow taper method, you can expect some Withdrwal symptoms with Nortrip, but they should be less severe than the withdrawl from many other AD meds I have taken.

I wrote that under the assumption that you will not be replacing the Nortrip with another AD medication.

Hope that helps
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Avatar universal
Hi,  I don't have any first hand experience with nortrilen, however, I think with any medication that you have been on long term it is always better to reduce the dose very slowly - I am surprised that your doctor didn't at least go through this with you - very lax on his part.

Suddenly stopping a medication will quite often result in withdrawal symptoms.

How high is the risk of damage to your liver and kidneys?  Have the levels in your blood been checked?

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