my mother (77yrs.of age) has been taking 10mg lexapro for general depression and body aches. Today, the physician said he wanted to give her something that would make her feel more "perky" and changed her script to 150mg Effexor. The instructions are to take 1 pill/day and to stop the lexapro. From my reading it seems that these meds should be weaned. Before she gets started, I was wondering if the physician's instructions seem reasonable or if there should be some type of weaning on/off schedule. It also seems to be a huge difference in dosage- or is that simply because of the nature of the drug itself? Mom is also saying that this is more expensive and I am worried she will just stop taking the Effexor when the time comes to renew. This is a scary thought having read several remarks regarding "coming off'" this med. And no- I am not exactly sure why the doc wants to change meds. I am seriously interested and most appreciative of any comments/suggestions. thank-you.