Had the same problem with three dematologist. All same thing, exfoliative Keratolysis, nothing to do, supportive theorapy, no curing.
However, you are the 226th person that has followed the exact path as my five year battle with this ailment.
Did the excise yesterday, everything is on the horse blood petri dishes since 6 pm last night. Monday afternoon we will read the plates. And I believe nail this thing to the wall. I am careful not to release the hypothesis in advance. So I sent the samples for blind or unknown culturing, with the exception of specifying horse blood agar. This thing on my thumb may have finally revealed the missing piece to the puzzle.
We will know Monday. And if I am correct, and the doc thinks I am, we will offer a cure to about 26 percent of the people afflicted with our varient.
Which will bring them closure, but open up new testing for me as this has to be a mutate because of its adhesin properties.
The day goes by you should notice it getting drier and drier, then flaking or cracking?
Talk at you Monday.
I have been dealing with a simular problem for the last 4 years. My dermatologists says he thinks I have hand exzema. He did a scrapping, and declare that it wasn't a fungal problem. Basically, My fingers (Especially my thumbs) become hard & calussed looking, feel dead and look pale, then begin to "blow out" & peel in thick layers. They become very sensitive & raw as the skin peels. Then a thin layer of reddish new skin forms. Sometimes they peel again before healing. They usually completely heel after 2-3 weeks and then the process begins all over again. This problem happens on both hands and seems to be semmetrical between the two hands. I have tried several cortizone creams including Diprolene AF .05%. No relief. Could this be something else? I never had this problem before 4 years ago. I am 31 years old. Do you have any ideas on what is happening?
Yes I am most certain that I peeled some of the skin from the sole under the big toe with my fingers, and some I may have cut it off. The plantars looking thing was a round callous on the top of a toe, with a hardened area in the center. I may also have pick at it with my fingers, specially after it dried out and stopped hurting.
Most definitely, in my case, it has been slowly spreading down my right thumb, and the problem becoming more frequent and more difficult to get the skin back to normal.
I read about the yeast/mold Penicillium marnefei which can have minor effects on healthy people with normal defenses, whereas it can be a serious problem in HIV affected people. I was wondering about this, but you said you had already cultured part of the skin and came out negative for fungus.
I saw a dermatologist but said it was soriasis or ezcema, and did not want to investigate any further, even though it is such a unusual occurrence to have it only on one thumb. I will be very interested on your results.
Keeping my thumb covered on a greasy stuff for the last 24 hrs seems to be helping more than the more absorvent cream. Also in the morning when I wake up is always better, and as the day goes by gets worse.
Did you peel the thick skin on your toe with you fingers and thumb?
The plantars looking thing, did it make an almost perfect circle?
Tomorrow we cut the thing from my thumb. It will take three days for the labs to come back.
I am back to thinking we are dealing with a slow growing bacteria. I used a woods light on the areas yesterday and got the results I was hoping for, so on to the cutting Thursday and by Monday we should know something. The good news is, if this turns out to be the bacteria, there are two treatments that can be applied.
Have you ever had large amounts or thick chunks of skin peel from your feet?
Or have you ever had lots of little pock marks in you feet around the heel and/or ball of the foot?
I have also set up a UVC treatment system. After the cutting experiment is over I am going to try a UVC method at 26,000 mW cm2 to see if I have hammer the RNA and DNA of anything it might be. This is high enough to hammer mold as well. Still working on the index finger protection glove. Once completed I will begin treatments and see what the he11 happens. This box also creates a lot of O3 so I had to ventilate it to my lab hood. I can produce 66,000 mW cm2 if required, but I have not found much that can survive 24,000 at this time.
Will report here as I continue. I could not find a derm Phd to work with me, they all tell me it happens. I am 45 years old and am not living with this. I will figure out how to kill it.
I am a research scientist, so I have theories, but no real answers. I am still trying to gather info to try and reach a logical conclusion. So far:
I thought it was a bacteria type deal, took antibiotics which did make it go away but it came back after going off the 14 day course. Came back at it with a double strength course for 21 days, went away but came back.
Switched to cortisone, made it worse IMO.
Went on a 60 day course of prednisone, stepped all the way up to 20 mg then backed down over a three week period, no effect
Went to iodine at 2 percent and wrapped it, killed it off and was clean for six months, started using vicks vapor rub and it came back. Suspected something living in the Vicks. Frozen for later analysis. Mean time it came back again without the Vicks, but seemed hooked to when I wear leather gloves. Started thinking maybe an alllergy to petro products? Iodine tinture works to kill it off, but it comes back.
However this time it has jumped from my index finger to my thumb on the same hand. Funny it started as a wart like thing on my index finger, almost like a planters wart, then cratered out dry no fluid, then the peeling began in ever increasing rings. Then it would start again, but never again with the wart type thing after that first time it always starts like my finger has been dipped in wax or part of it in wax, then gets hard, then starts to peel off, this time on the index it went up over the top, but did not go lower then the second joint. However it jumped to the thumb.
So it started feeling like a pimple, then cratered out dry, now has a typical perfect white circle about 5 mm across. It is slightly irritating and I can feel a bulb of irritated flesh under it. This condition existed last time for one month prior to total peeling starting.
So Thursday I am paying my family doc to numb me and cut it out. He agreed to do it if I promise not to use the carbocaine for my horses to numb it and do it myself. If this keeps it from spreading to my thumb like it did on my index finger I will at least know it spreads on the dermis. (integuement? that is what we call it on horses anyway)
Couple things that have me wondering. I used to get cold sores, I started using zovarix to kill the thing down, this showed up a year later, and acts sort of similar, in the fact it feels irritated then craters out then peels. Don't know if it is some new way for herpes to come out, but I have to keep it in mind.
I don't think it is bacteria anymore, I am pretty sure it is going to be a virus which if the cutting stops the spread I will pursue,
It has also occured to me that it is some type of reaction to environmental conditions. Causing a biological response that is dorking the dermis up, but I have largely discounted this do to the regional area it confines itself too. Allergic in one finger?
I continue to investigate and write in my lab book.
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brethens! I have the same problem i.e painless peelings on palm and feet. I started taking griseofulvin tablets this night. You may try it. Hope it works!
I am 34 years old and have lived with this problem dice I was an infant! And to make matters worse my hands from finger tips to wrist will peel layers of skin often times down to red "new" skin! But I also have hyper active sweat glands and my hands are always soaked! Never had a fungus, infection, or medical issue. However, it can get very painful, embarrassing, and inconvenient! I do however have the softest hands ever! A plus. I have yet to find anything that helps, prevents, or stops either from happening! I hate it! And every doctor who I've seen for it cannot give me an answer! Oh, normally the onset to a peel will begin with hundreds of red pin ***** looking bumps all over the palms and fingers! The hands will swell. This process is very painful and can itch! But it will go away and the layers of skin will then peel.
I too have the same issue. On top of thickened skin that peels on my thumb, my thumbnail is brittle. I've been dealing with this for about 4 years. I've tried tea tree oil, nail fungus treatments, etc. I decided to have my nail tested for a fungus and it came back negative. The strange thing is the test showed a high level of yeast. So after researching my symptoms further I'm going to try some of the suggestions I've read. I found three that seemed promising. 1.Threelac and Oxygen Elements Plus 2. Symbion Probiotics. 3. Vitamin A & B Complex along with immune building herbs. Keep you posted! KP
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