To answer your questions:
1) It is possible for an enlarged spleen to cause some of the symptoms you describe.
2) Pancreatic cancer can be difficult to diagnose. A negative CT scan would make it less likely. Further testing can be done with an MRI or endoscopic ultrasound.
3) Cannot answer that without evaluation. Further imaging of the pancreas can be done with the aforementioned studies. If negative, pancreatic disease is extremely unlikely.
4) Further testing can be done with a 24-hr pH study or gastric emptying scan. These tests can evaluate for GERD or gastroparesis respectively.
These questions can be discussed with your personal physician.
Followup with your personal physician is essential.
This answer is not intended as and does not substitute for medical advice - the information presented is for patient education only. Please see your personal physician for further evaluation of your individual case.
I have had the pain you are referring to for the past 2.5 years. It started for me, with a really bad case of acute pancreatitis. (the worst case my hospital had seen in over 20 years). Anyways, last August I had more than the normal pain, and they did a CT scan and my Spleen was enlarged. I went back to my surgeon and he did an ultrasound of the spleen. They found that there was a thrombus in one of the vessels that was causing a back up of blood in the spleen and in the vessels surrounding my stomach, which caused varices there. They then removed my spleen and things got much better after that. I have since had more of the increased pain, but that is due to progressing to chronic pancreatitis. I got the pancreatitis from high levels of blood triglycerides. Not a fun thing to have, but when you get the first acute cases of pancreatitis your amylase and lipase levels would be very high. Now that I have the chronic version, the levels no longer raise. Just thought I would put my two cents in!!
How painful was the spleen surgery?
For the spleen surgery, you first have to have a bunch of immunizations, since when you don't have a spleen anymore, you will be immunocompromised. Especially the Menningococcal and pnuemonia vaccines. Those aren't that bad. The spleen surgery for me was rough as far as blood loss goes, I had to recieve several units of PRBC's afterwards. I also had a ventral hernia repair with mesh placement when they did the spleen removal. So, the mesh placement was VERY painful. I don't think it would have been half as bad if the spleen was the only thing they had worked on.
They diagnosed the spleen thrombus via slenic ultrasound, and the varices via upper endoscopy. Maybe ask for those tests and you can find out more.
Hope that helps some.
A related discussion, gastric problems