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Elevated liver enzymes
Waiting on my Doctor. What could be my diagnosis? I had labs done this week and the elevated levels were AST 62, ALT 184, CK 260, GGT 136.0 and all other labs were nominal. No hepatitis A,B or C. Ultrasound showed enlarged liver and scheduled for CT Scan. I have had mild acid reflux and diarrhea everyday for 2 weeks, pain on my right side and back, nausea, fatigue and dizziness. I am a non-drinker since college 6 years ago. I am obese at 5'11" 290 lbs. Thanks.
MEDICAL PROFESSIONAL
Hi!
Ok let us try and narrow down the diagnosis until you can see your doctor.
Many a times AST (SGOT) and ALT OR SGPT (both are collectively called transaminases) rise without any cause. Because AST is found in many other organs besides the liver, including the kidneys, the muscles, and the heart, having a high level of AST does not always (but often does) indicate that there is a liver problem. For example, even vigorous exercise may elevate AST levels in the body. However to reach at that conclusion the medical causes of these raised transaminases have to be ruled out. Causes of liver transaminase elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. Steatosis and cirrhosis are ruled out by the ultrasound.
Other common health conditions, such as diabetes, heart disease, pancreatitis, hemolytic anemia and thyroid disease, can also cause liver transaminase elevations. Most liver diseases are characterized by greater ALT elevations than AST elevations except cirrhosis and alcohol abuse. ALT also rises in bile duct obstruction due to stone or tumor.
Greater-than-normal levels of GGT may indicate: congestive heart failure , cholestasis (congestion of the bile ducts) , cirrhosis, hepatitis , liver ischemia (blood flow deficiency), liver necrosis, liver tumor, high alcohol intake, use of hepatotoxic drugs (drugs toxic to liver).
So, since the ALT rise is higher than that of AST and GGT is high, the cause is probably in liver. Since liver is enlarged and you have acid reflux and diarrhea, bile duct obstruction and cirrhosis (does ultrasound mention this?) will have to be ruled out. Alcohol related causes are ruled out since you have not been drinking for long.
A rise in CK could be due to heart involvement secondary to lover or due to muscle activity or hypothyroidism.
Since I cannot examine you and know other related conditions you may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into and tried to narrow down the possibilities. Please discuss this with your doctor. Take care!
I sincerely hope you will find this information useful in your journey towards better health.
Hope you get well soon! Good Luck and take care!
Ok let us try and narrow down the diagnosis until you can see your doctor.
Many a times AST (SGOT) and ALT OR SGPT (both are collectively called transaminases) rise without any cause. Because AST is found in many other organs besides the liver, including the kidneys, the muscles, and the heart, having a high level of AST does not always (but often does) indicate that there is a liver problem. For example, even vigorous exercise may elevate AST levels in the body. However to reach at that conclusion the medical causes of these raised transaminases have to be ruled out. Causes of liver transaminase elevations include viral hepatitis, alcohol use, medication use, steatosis or steatohepatitis, and cirrhosis. Steatosis and cirrhosis are ruled out by the ultrasound.
Other common health conditions, such as diabetes, heart disease, pancreatitis, hemolytic anemia and thyroid disease, can also cause liver transaminase elevations. Most liver diseases are characterized by greater ALT elevations than AST elevations except cirrhosis and alcohol abuse. ALT also rises in bile duct obstruction due to stone or tumor.
Greater-than-normal levels of GGT may indicate: congestive heart failure , cholestasis (congestion of the bile ducts) , cirrhosis, hepatitis , liver ischemia (blood flow deficiency), liver necrosis, liver tumor, high alcohol intake, use of hepatotoxic drugs (drugs toxic to liver).
So, since the ALT rise is higher than that of AST and GGT is high, the cause is probably in liver. Since liver is enlarged and you have acid reflux and diarrhea, bile duct obstruction and cirrhosis (does ultrasound mention this?) will have to be ruled out. Alcohol related causes are ruled out since you have not been drinking for long.
A rise in CK could be due to heart involvement secondary to lover or due to muscle activity or hypothyroidism.
Since I cannot examine you and know other related conditions you may be having, nor is a detailed history possible on net, I have listed the various possibilities that should be looked into and tried to narrow down the possibilities. Please discuss this with your doctor. Take care!
I sincerely hope you will find this information useful in your journey towards better health.
Hope you get well soon! Good Luck and take care!
Thank you for your response. I have a CT Scan Scheduled for tomorrow. Hopefully that will provide answers. Just got my results for PROTEIN ELECTROPHORESIS SERUM which came back nominal. My condition is remains the same. Would you recommend any other test at this time?
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