My son Michael is now 13 years old and had Downs. He has always been very high functioning, very active in church, school. His speech while slurred was pretty good. He could work his dvd player, make a bowl of cereal, work the computer, and loves to sing gospel songs. He never met a stranger, we would have to sometimes hold him back because he wanted to hug everybody. This past September we bought a new house and he started attending a new school. In December his moods started changing, he was not sleeping and was scared of everything. He would not eat and started talking to people that were not there. It seemed as if he was regressing. He was talking less and could not write as well as he used to. He seemed to forget how to wipe after using the bathroom. We took him to a doctor who prescribed respiridol and he had a very bad distonic reaction to it. We took him to another doctor and she put him on celexa and other meds that I can't spell or pronounce. he seemed to have a reaction to everything he took. Things came to a head this past Sunday when he started flailing about uncontrollable. We rushed him to the hospital emergency room and during 5 days they ran every test they could come up with. All tests were negative, eeg's, mri's,, sleep study's, we were told that there was nothing medically wrong. He still has the symptoms of being scared, talking to people who are not there, not sleeping, and decreased eating. I just want my little boy back the way he was, but we are being told now that these are things that happen in children with downs. At this point we don't know how to help him. They have now put him on drugs to improve his mood and clonidine to help him sleep. Has anyone seen this before, how can I help my son. I don't except that he will be this way from now on.