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MTHFR C677T????
Hey all!!!! I just wanted to ask what this means???? I tested positive for one copy of this, but has anyone else????? and what did they do for you?????
Jacquie
Jacquie
Hey there. I have both the MTHFR C677T and A1298C. I have struggled with miscarriage after miscarriage. I was fortunate enough to have a beautiful little girl a couple of years ago and we are trying again. What I have found to be the most important part of having this mutation is finding a doctor that knows what this is. I have had a couple (we have moved around and needed to find new dr's) that had no clue how to help and all of my miscarriages were with these dr's.
I am now working with a perinatologist in Columbia, MO and an excellent OBGyn there as well. They know what they are talking about and that has brought my level of anxiety down - which is important as well.
I am on heparin (blood thinner), baby aspirin, l-methylfolate (which is the broken down form of folic acid). The l-methylfolate is due to our bodies not able to process folic acid. That is why dr's increase the folic acid recommendation to 4 - 5 mg during pregnancy. They also suggest taking b6 and b12. My OB has also suggested staying away from refined sugars (enriched flour, donuts, ect.) he thinks a Mediterranean diet is a good diet to follow.
It is also important to remember that the whole pregnancy should be viewed as high risk. Not just the first trimester. Your dr can give you more information on this.
Please know - for those that have the miscarriages, you can do this. We pushed through after 3 mcs and now have a perfect child. We had another mc after her (when we started trying again). But I know that we can do this. My Ob's nurse also has had a successful pregnancy.
Good luck and remember that there are Dr's out there that know exactly how to help you. We drive an hour to see ours. It is worth it.
I am now working with a perinatologist in Columbia, MO and an excellent OBGyn there as well. They know what they are talking about and that has brought my level of anxiety down - which is important as well.
I am on heparin (blood thinner), baby aspirin, l-methylfolate (which is the broken down form of folic acid). The l-methylfolate is due to our bodies not able to process folic acid. That is why dr's increase the folic acid recommendation to 4 - 5 mg during pregnancy. They also suggest taking b6 and b12. My OB has also suggested staying away from refined sugars (enriched flour, donuts, ect.) he thinks a Mediterranean diet is a good diet to follow.
It is also important to remember that the whole pregnancy should be viewed as high risk. Not just the first trimester. Your dr can give you more information on this.
Please know - for those that have the miscarriages, you can do this. We pushed through after 3 mcs and now have a perfect child. We had another mc after her (when we started trying again). But I know that we can do this. My Ob's nurse also has had a successful pregnancy.
Good luck and remember that there are Dr's out there that know exactly how to help you. We drive an hour to see ours. It is worth it.
Promise us when you have your babies not to forget to inform us. We all really need a happy ending story!!! Please!!! Hope all the girls are with me on this.
Faith--so sorry about your loss. I would definitely make sure that you are tested for thrombophilia issues when you decide to ttc again. Third tri losses are often due to clotting disorders. Have them do the the recurrent miscarriage panel (the common name). It is about 9-12 vials of blood for the whole panel, so expect them to take a lot. MTHFR can be a contributor to your baby's death, but it wouldn't surprise me if there isn't more happening to.
I wish you well with your marriage and ttcing.
Ashort--Sorry for your mc. After my first mc I wanted to be tested for clotting, but I let my doctor convince me it was bad luck or bad eggs. When the second mc happened, there was no way I was leaving until he gave me those bloodwork slips!!! I think the doctor was surprised when something actually showed up with the bloodwork (mthfr and protein s deficiency). I see only the RE and I still trust him despite him not listening to me. I take that blame on myself...I learned to be my own advocate from that and to remember they are only human.
I wish you well with your marriage and ttcing.
Ashort--Sorry for your mc. After my first mc I wanted to be tested for clotting, but I let my doctor convince me it was bad luck or bad eggs. When the second mc happened, there was no way I was leaving until he gave me those bloodwork slips!!! I think the doctor was surprised when something actually showed up with the bloodwork (mthfr and protein s deficiency). I see only the RE and I still trust him despite him not listening to me. I take that blame on myself...I learned to be my own advocate from that and to remember they are only human.
Ok so I stopped reading when I finished baby1234's first post. I had a stillborn at 27 weeks in 2004. The umbilical cord had formed very small at her belly button and a blood clot had stopped the blood flow to her. The Dr. did not exactly explain to me how it happened or do any sort of testing. I know I have clots all the time with AF. This sheds a new light on things for me. I am getting married again soon and we will be going to a Dr. to try and conceive. I am going to inquire about this from the beginning. Thanks for everyone posting on this subject.
I just reread the email my RE sent me. I am compound hetero. MTHFR. He has me on Folbic (which have extra vitamin B and folic acid in them. I'm also taking a baby aspirin a day...I'm so glad to hear you are doing well. It gives me hope. I had a m/c in June and demanded that I was tested and it was such a good move. I love the website you posted above. It was so informative. Do you see a reproductive immunologist or just an RE?
Heterozygous is one gene mutation of either C677T or A1298C (your category and least worrisome)
Homozygous is two gene mutations of either C677T or A1298C (the most severe)
Compound heterozygous is one gene mutation of each C677T and A1298C (what I have and second most severe)
I'm not sure which mutation you would have, you would need to check with your doc. You are most likely okay as long as your homocysteine levels stay within normal range. If you are concerned about your levels you might have your doc check your homocysteine levels again to verify results.
Are you on extra folic acid and B vitamins? Your doc can prescribe the folic acis and b vitamins to keep your homocysteine levels in check. (prenatals don't have enough folic acid to do this) They also have supplements over the counter if you want to add this to your diet on your own. Whatever your body doesn't use/need is ejected without harming you. You can google mthfr to find out recommended amounts of each vitamin to help you out.
Good luck!
Homozygous is two gene mutations of either C677T or A1298C (the most severe)
Compound heterozygous is one gene mutation of each C677T and A1298C (what I have and second most severe)
I'm not sure which mutation you would have, you would need to check with your doc. You are most likely okay as long as your homocysteine levels stay within normal range. If you are concerned about your levels you might have your doc check your homocysteine levels again to verify results.
Are you on extra folic acid and B vitamins? Your doc can prescribe the folic acis and b vitamins to keep your homocysteine levels in check. (prenatals don't have enough folic acid to do this) They also have supplements over the counter if you want to add this to your diet on your own. Whatever your body doesn't use/need is ejected without harming you. You can google mthfr to find out recommended amounts of each vitamin to help you out.
Good luck!
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