Hello and thank you.
I was mostly concerned about the pancrease and liver, but understand that things don't really change in just four years. At least that's what I think I read.
Our weight will fluctuate up to 5 lbs, so if it's only a few pounds I wouldn't worry. If you're not feeling well, or are having pain then that's different and you should see your doctor. You're one year away from having to have regular colonoscopies, it's okay if you want to have it a little earlier if just to ease your mind. I hope this helps and best wishes.