Hysocyamine?

[sqwak1200]

Has anyone used Hysocyamine?  I just started this medication  today.  I was treated for H. Pylori last year and since then I have been suffering from Water Brash.  So far I have been on Prilosec, Prevacid, Aciphex, Protonix, Nexium and Zegerid.  None of these drugs gave me any relief for the Water Brash.  The GI said Hysocyamine is an anti-spasmatic med which reduces saliva output.  I have nothing to lose so I am taking 0.125mg three times a day.  

Today I did  have moderate burning sensation just above my navel about 90 minutes after lunch.  It feels like the same Gastritis pain I used to have when I had H. Pylori.  I sense it could be PPI bounce-back effect.  I left a message at the GI's office and asked if I could take Zantac along with the Hysocymaine.  So far no reply.  In the past GI said it was safe to take up 300mg of Zazntac  a day(WTF).  It sounded like a lot.  Zantac usually comes in 75 or 150 MG pills.

Any feedback would be appreciated. At this point I am functionally disabled because of the Water Brash and post H. Pylori complications because of the need to spit all day and all night(therefore little sleep).  I have to solve this problem very soon.
I am running out time because I have to go back to work.

[shurely]

Thanks for the information. I will check it out and I'll get back to you.
Thanks again!

[ohiogirl]

Hey Shurely,
I have the same story as you, GB removed and same pain, even worse actually and more frequently, after the GB removal.  My surgeon (GB surg.) thought I was crazy, I was in so much pain, I did a lot of research adn asked him about SOD.  He said, "there is no way, it's way too rare."  Jerk.

So, I FINALLY got my OB (surgeon wouldn't do it) to refer me to a GI, the new GI believed it was SOD and sent me to a specialist at Indiana University.
Unfortunately, the only way to try to treat SOD is with meds first, then more drastic measures by using ERCP with manometry and possible sphincterotomy.  And that is very risky as many times it can cause varying stages of pancreatitis.  So far I am not at that phase of my disease.

I am on Hycosamine and another drug called Elavil, it's an anti-depressant prescribed for its side effects on pain.  I wonder if your doc suspected SOD as it's an anti-spasmotic supposed to work on smooth abdominal muscles.

So far, I am thanking the Big Guy up there as these meds for me have been a life saver.  My SOD is still here, but way, way, way more under control and I'd easily call it 'liveable.'

I'd love for you to learn more - I am part of a great support group on Yahoo if you are interested.  I don't know the rules about posting stuff like that out here, but I'd love to have you join.  This group is for sufferers of SOD, Pancreatitis and other digestive diseases.  

I think it would be helpful for you!
Let me know!

[shurely]

So, they use hyoscycamine to treat SOD also? I've been wondering if that may be my problem since I had my GB removed and still have the same 'attacks' as before. My dr. prescribed it for me before they removed my GB and he didn't have any idea what was wrong but I figured if it helped it didn't really matter. I still haven't been dx. with SOD or anything (I haven't been back to dr. since I had my post-op visit after GB surgery. I didn't see any point you know?) I don't think I have any other spare parts! Is that the only treatment you get for it? Sorry for the change of subject but thanks

[shurely]

Is the hyoscycamine helping any today? I hope you're feeling better.

[ohiogirl]

Squak - you may want to ask about getting a script for the .375 dosage, I agree with Shurely.  My sinuses, nose, throat, mouth, etc gets so dry, I have to use a humidifier at night and it still doesn't make a huge difference.  I drink lots of water during the day, and I'm still all dry.
For some reason, I find that people who are prescribed the Hycosamine are usually given the .125 dose first - no clue why.  I have suggested that many ask for the extended tab dose of .375, I just personally think it works better.  And, for your need for the side effect, it wouldn't run out on you halfway through the day.
good luck!  Keep us posted.  Thanks for the description of Water Brash!  I hope it helps, your condition would be very frustrating to live with!

[shurely]

Sorry it hasn't helped you yet. You may need to ask about increasing your dosage. When I take one of the .375 tablets it dries up my nose, mouth and throat right away. I usually get real hoarse when I take it. I hope you soon feel better. I've had heartburn that made my mouth water too.....it's awful!!

[sqwak1200]

Wow, I've been only taking two 0.125mg tab  twice a day.  I was afraid of some of the listed side effects.  After two days I haven't seem much improvement.  But I guess the dosage I am taking is very small.  I was told to take it on an empty stomach(30-60 min before meals).  
I will have to more patient.

Water Brash  is when excessive amonuts of saliva buid up in your mouth.  This is a symptom of Acid Reflux or sometimes when you have too much acid produced in your stomach.

Ohiogirl and Shurely, thanks for your input.
I

[shurely]

I too take Hyoscycamine on an as needed basis. I hate taking it because of the dry mouth and throat! It should be good for overactive saliva. It also says it is used for runny nose and stuff. I am prescribed the 0.375 tab which I thought to be 12 hr. extended release tab but my dr wrote it to take 1 or 2 tablets two times a day. I don't think I could stand that much!! It is a lifesaver for abdominal pain.
Good Luck and good health

[ohiogirl]

I take Hycosamine for Sphincter of Oddi Dysfunction.  It has helped my condition immensley, but it sounds like he's prescribing it to you for it's very common side effect of dry mouth.  I can tell you, it does cause dry, dry arid dry (did I mention dry?) mouth, so if you have over production of saliva, this may be your ticket.
I used to take it with an "as needed" dose, but I highly recommend taking the .375 dose which is a 12hr. release tablet.  It's a lot easier to remember to take it, and just less maintenance overall.
I am extremely unfamiliar with Water Brash, so please forgive me if any of what I am saying makes no sense at all.
One more thing...raw veggies are one of the most difficult foods for our bodies to break down, and tummies to digest, so although I am a huge fan of high fiber, sometimes it helps to stick more toward veggie stir fry, soups, or just cooked veggies in general.  
Good luck!

[sqwak1200]

Ggreg,  thank you very much for the response.  I eat yogurt with the good bacteria and I also take a priobitic (Natrens Healthy Trinity).  Also, I am on a high fiber diet(salads for lunch).  Everything you say makes a lot of sense.

[ggreg]

I take Hyoscyamine on an as-needed basis.  I began taking it a couple years ago daily when I had IBS.  I would get this deep down indigestion, and it was the only medicine that stopped those crampy feelings and helped the diarrhea I had daily for six months.  My IBS eventually improved when I stopped another medication I was on, but I remained sensitive to some foods, so I still occasionally take it.  About the only thing unusual about this medicine is it makes me sleepy.  I think it's a good drug.  I do not think there is any harm in taking a second digestion medicine, becuz my doc had told me to also take an antacid when she prescribed the Hyosyamine, altho I ended up not needing the antacid.  But my indigestion is different than yours, so you may need both.

I take three different things for my indigestion, depending on where it is.  If it's a tummy nausea thing, I take Tums.  If it's gas pain in my upper guts, I take Alka Seltzer.  If it's low cramps, I take Hyocyamine.  Also, when I had IBS, I tried some Activia yogurt, it has acidophilus "good" bacteria in it, helps break down digestion, and gosh it helped me a whole lot with the diarrhea I had.  And I am a big water drinker, I try to exercise regular, even a little bit, and those things keep the digestion working better.  Also, I find soothing to an acid stomach 100 percent whole wheat bread, soaks up acid.  By the way, on an empty stomach, you can eat some bites of canned pineapple chunks, it's a natural disinfectant to the digestive tract.  And salads are very good fiber, keeps the waste moving.

It is not normal to need to spit day and night, and you should not have such an upset tummy all the time.  I don't know if this makes any difference, but it's okay to swallow your spit, do not worry what it will do to your stomach, becuz obviously spitting is not helping!  Having a lot of excess mucuous sometimes indicates an infection is going on in the body, it's how it rids itself of toxins.  Take you temperature, see if you have a fever, which combined with the mucuous means you still have an unresolved infection.  If your doc is nonresponsive, a second opinion makes sense.  Swallowing your spit a lot might make you a little woozy, but beats the heck out of hacking it up.  

You can try some of the stuff I've done, every little bit helps.  You should notice the Hyocyamine helping you within a couple days.