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Avatar universal

antibodies and prednisone

hi doctors I have been reading about the affect of Prednisone on the production of antibodies even in this site I have read that it can delay antibodies this has me concerned because I was on prednisone 40mg a day for 5 days a week before my risk.  I took my last pill exacly 3 days of my oral sex risk.
I recived oral from a girl from work and the next day I noticed she had really bad gums since she is a smoker, also I am uncircumsise and the next day u noticed she brused my foreskin but I did not see an actual cut. I had all the ars symptoms, I tested at 8, 13, and 15 all neg but how reliable are these results since I took prednisone.
Ps
After my 13 week test iwent a whole week with sore muscles which is the reason I took my 15 week test.
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239123 tn?1267647614
MEDICAL PROFESSIONAL
"Please do your best to ignore any further "what if" scenarios that may come to mind.  There are no scenarious you could think up that would change my opinion or advice."

Your doctor is just being careful and conservative.  Any and all further HIV tests you have in the future will remain negative, assuming you have no new sexual or blood exposures.

That is truly the last comment on this thread.
Helpful - 0
Avatar universal
Hi doctor
Sorry for coming back but I just want you opinion one last time.
I have been suffering from muscle aches around my arms, neck and legs along with joint pain on my toes and fingers, I have had a few scattered swollen notes on my neck and under arms and groin area.
This all started a week after my 13 week test and its been a month now and still have some swollen glands. I went back to my doctor and he did
Lyme, ana/reflex, cbc, esr and parvovirus test and all came back normal now he wasnts me to take another hiv test and I am freaking out.
What are the chances of turning positive after 13, and 15 week test?
Now I'm reading on the positive forum how some of them had a negative test at 13 weeks and still turned out positive at 6months pls, pls don't ignore me, I just want your opinion on this one last time
Thank you
Helpful - 0
239123 tn?1267647614
MEDICAL PROFESSIONAL
Sigh.  If you will read and absorb all my comments above, you will understand that this makes no difference.  Even if you had been tested while taking the prednisone, with maximum blood levels, it would have no effect.

Please do your best to ignore any further "what if" scenarios that may come to mind.  There are no scenarious you could think up that would change my opinion or advice.
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Avatar universal
Hi doctor
As I read my post I noticed I made made a typo.
When I said I took prednisone a week before my risk I meant to say a month and a week before my risk.  Does that make my test even more reliable? How long does prednisone stay in your body?
Helpful - 0
239123 tn?1267647614
MEDICAL PROFESSIONAL
You're asking essentially the same question using different words.  Your test results PROVE you don't have HIV and therefore cannot have ARS.

Thanks for the thanks, and for the symbolic beer.  But it will honor me most if you take this advice to heart, put your regret over a sexual choice you regret  behind you, and move on.

Take care.
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Avatar universal
Thank you doctor you don't know how much you have helped me.
A simple thank you would no be enough but since I can't buy you a beer a thank you will have to do.
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Avatar universal
Ok last one I promise..if I had ars regarless of my prednisone treatment would I have shown positive at 13 or 15 weeks? My symptoms started 2 weeks after risk and lasted for 2 weeks.
Helpful - 0
239123 tn?1267647614
MEDICAL PROFESSIONAL
Since you are proved not to have HIV, of course it is safe to have sex with your wife.

If I had been in your situation, prednisone or not, after such an exposure I would not have ever had an HIV test.  And I would never have stopped having unprotected sex wity my wife.
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Avatar universal
Thank you doctor, one last question before I put this to rest.
Is it safe to have unprotected sex with my wife? If you were in my shoes based on my risk, prednisone treatment and test results would you have sex with your wife?
Thanks for your time
Helpful - 0
239123 tn?1267647614
MEDICAL PROFESSIONAL
Welcome to the forum.  Thanks for your question.

In theory, potent immunosuppressive therapy might delay development of antibody and hence a positive HIV test.  However, I stress "in theory":  to my knowledge, no such cases have actually been reported in the medical literature.  And although you took a hefty dose of prednisone, it's not all that potent compared with other immunosuppressive drugs, and only 5 days treatment is unlikely to have had any effect at all.

Further, you had an essentially zero risk exposure, because a) it is statistically unlikely your partner had HIV (probably under 1 chance in a thousand); and even if she did, HIV is almost never transmitted by oral to penile sex.

Based on both your test results and your exposure history, you can be 100% certain you didn't catch HIV, regardless of your prednisone treatment.  You have been over-tested already and certainly no further testing is necessary.

In case you are interested, here is a link to a thread that discusses HIV test reliability and timing in detail:

http://www.medhelp.org/posts/HIV-Prevention/what-is-the-window-period-for-hiv/show/1704700

So don't worry any more about it.  All is well.  HHH, MD
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