Aortic Aneurysm - Losartan study on mice shown to reverse size of aneurysms???

[Shidaddy]

Hi. I have two questions:

1) Do I need surgery soon?

I have recently been diagnosed with an aneurysm of my aortic root of 4.8cm and also my ascending aorta of 4.9cm. My aortic valve is trileaflet and still in good shape. My ascending aorta is 1.9 x the diameter of my descending aorta.

- I'm a 41 year old male
- 6'2" and 210 Lbs.
- I'm athletic (or I was before my diagnois)
- I do NOT have marfans syndrome, but apparently a connective tissue disorder.
- I have a history of "massive heart attacks" on my mothers side (no autopsies were done)
- I feel fine. If it wasn't for the CT scan findings I would not realize there is an issue.


2) Cozaar/Losartan: Is there a chance that I can avoid surgery by taking Cozaar. If so, how much should I take each day?

I just read about a study on mice with marfan syndrome. Apparently, their aneurismal aorta

[sasquatchbreath]

Should I be worried or am I making something of nothing?

[crystalhanzelka]

Not here to scare anyone, but my aunts friend just died of this.  They told her she did not need surgery and then it ruptured.  She was however like 60 something and a big time smoker and drinker.  I am sure this played a key factor into hers rupturing.  I just wanted to put this out there and I know some will be upset.  And I am sorry....

[NTB]

I think that's valuable info, Crystal. Keep up the good work.

[sasquatchbreath]

What was the size of your Aunts friends dilation and was it on the aortic root.....  

ie do you really know enough about this persons condition to know we are talking apples to apples?  I know very little about my Aunts friends medical conditions or causes of death.

I appreciate the sentiment, but do you really know enough about the situaiton to provide added value here (maybe you do.... just asking).

[Aha367]

What were your measurements this last appointment?  I hope it went okay.  

[stevesheart]

Hey all,
Interesting stuff.  I want to thank whoever it was out there that first posted about Cozaar, Losartan, and valsartan it all sounds promising.

My name is Steve and I am a 34 year old male.  I was diagnosed at birth with a bicuspid valve.  I have never had any symptoms with this and have always had an active normal live.  6'2" 180lbs.  
Last summer I decided to get a CT done since I hadn't in over 10 years.  Well I wish I would have done it sooner as my ct discovered an aneurysm of my ascending aorta of 4.9 cm.  I was put on 50mg metoprolol daily but nothing else.  I have had 2 ct's done since last July and I am still stable at 4.9 cm.  I am encouraged about these drugs that may slow the growth or reverse it of the aneurysm as I would probably be able to avoid surgery until my valve possibly needed to replaced in my 50's or 60's.  
I am going to contact my surgeon and cardiologist as soon as I can to see about getting put on one of these other drugs possibly.
Thanks again and best of luck to us all.
Keep the faith,
Steve