Aa
MedHelp.org will cease operations on May 31, 2024. It has been our pleasure to join you on your health journey for the past 30 years. For more info, click here.
Aa
A
A
A
Close
690060 tn?1247841741

FDA warns on Plavix + Prilosec

NTB
http://www.fda.gov/Drugs/DrugSafety/PublicHealthAdvisories/ucm190825.htm

"The U.S. Food and Drug Administration (FDA) has new data showing that omeprazole (Prilosec/Prilosec OTC)—a medicine used to reduce stomach acid—reduces the anti-blood clotting effect of clopidogrel (Plavix) by almost half when these two medicines are taken by the same patient."

"...Patients using clopidogrel should consult with their healthcare provider if they are currently taking or considering taking omeprazole, including Prilosec OTC"

but then, there's also this:
http://www.theheart.org/article/1025121.do
"Cardiologists shocked by new FDA alert on clopidogrel-PPI interaction"
2 Responses
Sort by: Helpful Oldest Newest
690060 tn?1247841741
NTB
hi, Madge, That website doesn't have the best technical web staff in the world. It might work if you try again, though.

Here's a sample of the commentary, where a cardio says: "I was shocked by the strengthened warning. Proper subgroup analyses from randomized trials, including CREDO, TRITON, PRINCIPLE, and preliminarily from PLATO and CURRENT, all indicate that no interaction exists... And then a preliminary analysis of data from the COGENT trial, a trial dedicated to specifically examining clopidogrel with a PPI vs placebo, fails to suggest even the slightest signal of a negative interaction. For the FDA to then strengthen the warning of a interaction is baffling, to say the least."

Also, IIRC the AHA and ACC haven't advised against the combination.
Helpful - 0
Avatar universal
I tried to copy and paste the second article you referred ot "Cardiologists shocked by a new FDA alert on clopidogral-ppi interaction," but was unable to access it.  Could you tell us what it says? (Thanks.)
Helpful - 0

You are reading content posted in the Heart Rhythm Community

Top Arrhythmias Answerers
1807132 tn?1318743597
Chicago, IL
1423357 tn?1511085442
Central, MA
Learn About Top Answerers
Popular Resources
Are there grounds to recommend coffee consumption? Recent studies perk interest.
Salt in food can hurt your heart.
Get answers to your top questions about this common — but scary — symptom
How to know when chest pain may be a sign of something else
A list of national and international resources and hotlines to help connect you to needed health and medical services.
Herpes sores blister, then burst, scab and heal.