hi, Madge, That website doesn't have the best technical web staff in the world. It might work if you try again, though.
Here's a sample of the commentary, where a cardio says: "I was shocked by the strengthened warning. Proper subgroup analyses from randomized trials, including CREDO, TRITON, PRINCIPLE, and preliminarily from PLATO and CURRENT, all indicate that no interaction exists... And then a preliminary analysis of data from the COGENT trial, a trial dedicated to specifically examining clopidogrel with a PPI vs placebo, fails to suggest even the slightest signal of a negative interaction. For the FDA to then strengthen the warning of a interaction is baffling, to say the least."
Also, IIRC the AHA and ACC haven't advised against the combination.
I tried to copy and paste the second article you referred ot "Cardiologists shocked by a new FDA alert on clopidogral-ppi interaction," but was unable to access it. Could you tell us what it says? (Thanks.)