on high hbsag levels: the longer on tdf the better, some trial had response after 3 years on tdf despite hbsag levels others after 5 years
when hbsag<1000iu/ml response was found on 100% patients and hbsag loss on 91%.patients were on antivirals many years
sequential means to take meds for a period of years, nothing that you asked there .
Stef, let me be clear one more time. Sequential, it means after 4 years or when hbsag is(less 1000) you add peg inter, but meantime tnf you don't have to interrupt? am I right?, and one more question; how long did you use Gcmaf? thanks
i understand the peg must be used after a few years of sequential, this in case you are strong enough to not develop any side effects like luckyman here who after not even a year developed both of them , bone density and high creatinine
you have to understand what they do, as we said already we already know the sequential that can rescue immune system and make pegintf hbsag clearance, all the rest is toilet paper, end of story
as we are posting from many years now the cure is tenofovir 5-10years and then pegintf add on when hbsag<1000iu/ml with 91% clearance, all the rest is not even useful to post here......do you see me posting about the wrong combination of peg and nucs?anybody by now knows how the combo must be used....
stef, don't you think is weird that so many posts are contradicting each other ? i mean look at luckyman's post about aasld poster, is just totally contradicting the results, i mean ,it's my first time when i have to learn about a disease but it is very confusing and frustrating to hear good news - bad news about the same thing every time
the only extremely interesting data of this study is:
tdf gets 50% of patients with hbsag less than 1000iu/ml by 4 years
this 50% can cure hbv in 91% cases by pegintf add on and the 9% without hbsag loss achieve extremely low hbsag anyway
nice, thanks for posting this ,
"particularly those with low baseline HBsAg levels. HBsAg decline is slow (>0.5 log10 in 36% of patients after 4 years) and is associated only with higher baseline serum IP10 levels."
so if i have a high hbsag baseline like mine , 350- 400k ,and also naive i would decline much faster ?
i dont see hbv cure so far, i still think it is in our hands and proper tests and combos of tdf, vit d3 and pegintf add on can cure most patients by 5-10years
After 4 years of therapy, HBsAg levels ≤100 or ≤1000 IU/mL can be achieved in approximately 30% and 50% of patients
50% of patients with hbsag less than 1000iu/ml by 4 years
not bad at all if you consider pegintf add on can cure 91% of them and maybe adding vit d3 or dr coimbra protocol of vit d3 may take this 50% even higher