i think some of us should try a combo with simvastatin now to see ourselves how it works, i dont think there will be any trial on this since sim is out of patent from many years and too cheap
my sister will have a visit to her doctor soon maybe she will start a combo with it
these trials are going on since so many years and interferon producer has finished trials years ago but they dont publish the results, i ve even stopped checking their website
from the small info we have interferon+truvada+alinia should have the biggest impact on hbv but i think we dont need those trials the best thing is to use these drugs off label since interferon monotherapy can lead to hbsag mutations and development of occult hbv, so in any case monotherapies should be avoided now
my point for now is to see what happens decreasing nagalase to healthy levels by gcmaf, as pisa researchers said is useless to try any immune therapy is immune system is not working due to nagalase
A reader from China's HBV forum posted this clinical trial:
http://clinicaltrials.gov/ct2/sh ... Hepatitis+B&rcv_s=05%2F01%2F2011&rank=3
Combination Entecavir and Peginterferon Therapy in HBeAg-Positive Immune-Tolerant Adults With Chronic Hepatitis B (HBRN)
It hasn't started yet. Hope they will get a positive result this time, with all the new tools available to them.
Any comments?
hbvnda and hbsag are extremely simple and following their directions there is no problem.the only danger might be if they mix samples when they receive it
yes we need both and we need also both immune therapy and nucs, nucs alone are totally useless
You may be right. I know they charge about $30 yuan for Abbott in China. So it is roughly the same as in Europe. I think it will be a while before it replaces quantitative hbvdna because it is not as straight forward to interpret as hbvdna. I think we really need both of them.
In China, a lot of people send their own samples of blood to hospitals where the machines are available for testing. This method worries me a lot, both for safety and accuracy reasons.
Any comments?
the cost of quantitative hbsag is very very low, 5 euros in italy, it can make hbvdna pcr useless or much less used.......hbvdna pcr is 160euro in italy.....
well exactly they are free by healthcare system for hbv carriers but if you make it privately or you are not hbsag carrier the cost is 5euro vs 160euro
i got why US and some other countries that can afford new machines are not using quantitative hbsag:
the cost of quantitative hbsag is very very low, 5 euros in italy, it can make hbvdna pcr useless or much less used.......hbvdna pcr is 160euro in italy.....
I posted your explanations to the Chinese HBV forum. Thanks, again.
You are absolutely correct. I miss-read the news that Siemen has a new quantative HBSAg system, in fact it is a new qualitative system, with a better coverage of the HBSAg mutants, just as you said. Many thanks for your explanation.
Correct me if I am wrong. I thought the Abbott system is completely automatic, so even if dilution is required, it will be done by machine?
no abbott has a small range 0,1-250iu/ml and of course no cronic carrier has such low hbsag as 250iu/ml, once 100-300iu/ml is reached clearance is close
the researcher in pisa told me that technicians can do mistakes with the pipe sometimes so the hbsag level can vary of about 500iu/ml
Or the dilution must be done by human?
diluition is required by human, infact many labs are so lazy to give result as >250iu/ml just because they dont want to take the pipe and make the stupid diluition.i think nowadays some techs are so ignorant using authomatic assays that sometimes we know more than them
The Roche's system, is it automatic?
yes and the range is superior getting to 52000iu/ml with no diluition
Do you know anything the new Siemen system?
the hospital in my town took it because it is the best as coverage of hbsag mutants, they collect donated blood so i think they changed architect because of this.
i know siemens doesnt have a quantitative assay, i called the hospital 2 weeks ago and thy are going to make hbsag quantitative again,maybe they are changing with roches machines
Correct me if I am wrong. I thought the Abbott system is completely automatic, so even if dilution is required, it will be done by machine? Or the dilution must be done by human?
The Roche's system, is it automatic?
Do you know anything the new Siemen system?