After 16 week with Interferron + Simvastatin

[Otan]

Took 1st dose on 21 Oct 2011 and on 11 Jan 2012 HBV DNA not detected.  
Below is the lab history,                          

Date            13/9  20/10  21/10  11/11  16/11  9/12  15/12  6/1/12  11//1/12
                                   1st dose                                   12th dose
SGOT                    35*                          49*             63*                  67*
SGPT                    63*                          78*             89*                  90*
HBsAg     366.44  255.68                                                              176.4*
HBV DNA2.54x10^5                                                                   no detect

Result on week# 16

SGOT  86
SGPT  130
HBsAg  10.49

When HBsAg became zero, then what to do? Is that time to stimulate Anti-HBs?

[stef2011]

when you reach 24 weeks of treatment we will check all studies with use of vaccine to boost hbsab, also remember to get vitd3, anyway i am sure you will develop hbsab soon

[Bob0620]

1. If Otan develops HBsAB, does it mean he is cured ?

2. If HBsAg is low, does vaccination effective to increase HBsAB ?

3. Is Simvastatin approved for HBV ? I've read they are still under trial.

[stef2011]

1. If Otan develops HBsAB, does it mean he is cured ?

he is cured even with no hbsab because most patients don t get hbsag or hbvdna back again bt it is easy to get hbsab by vaccine so it is better to try it at 24-48weeks of interferon therapy

2. If HBsAg is low, does vaccination effective to increase HBsAB ?

no hbsag must be 0iu/ml or less than 1iu/ml

3. Is Simvastatin approved for HBV ? I've read they are still under trial.

no it is not approved and it will never get approved because it is too cheap and off patent now but simvastatin is now proved to prevent liver cancer and fibrosis so all hbvers are suggested to use it with ast/alt monitoring

do not wait for an approval or a trial noone will pay for it because there is no payback sim is too cheap.the trial is blocked since 2009 i think and it will neer start

[lema2210]

May I ask what status you were in before treatment? Were you on antivirals before, your hbseg status, etc? Thanks.

[grmr]

i join lema2210 question.. pls inform about your status prior to tx.

were you hbv carrier since birth?
liver status?
eag status?
age?

are you experiencing side effects on iterferon?

[stef2011]

it can also be important if there was use of anticholesterol drugs/statins before interferon and how long

gmr:
she has reported mild sides in another post but i d not consider them sides because those are signs of immune activation