Antiviral Telbivudine Appears to Protect Kidney Health

[stef2011]

another study already found tenofovir plus telbivudine to be very potent and which improved kidneys malfunction of few patients.this might be a very good choice for those with kidneys problems or high creatinine

Antiviral Telbivudine Appears to Protect Kidney Health
The antiviral telbivudine (Tyzeka), may not be as potent as other hepatitis B antivirals, but it appears to have a unique quality—it appears to “protect” the kidneys against damage usually linked to antiviral treatment, according to an article in the December issue of the Journal of Viral Hepatitis.

Some antivirals, including adefovir (Hepsera), cause kidney damage, but in an unusual twist, telbivudine appears to somehow protect kidneys.

To evaluate how much kidney protection telbivudine confers, researchers monitored kidney (renal) function in 831 hepatitis B patients who received a combination of antivirals for 96 weeks, including:

Telbivudine and adefovir
Adefovir plus lamivudine
Adefovir plus entecavir
Adefovir alone
and entecavir alone
Among the five treatment groups, significant improvements in kidney function was observed in the adefovir plus telbivudine and adefovir plus lamivudine groups over the study period. Improvements were most significant in patients who began telbivudine when their kidney function was not up to par.

“In conclusion, our results suggest that the combination therapy of telbivudine and adefovir is significantly associated with renoprotective effects in chronic hepatitis B patients when compared with other adefovir-based combination or single (antiviral) therapies,” the researchers wrote.

Source: www.unboundmedicine.com
/medline/ citation/24351112/

[stef2011]

maybe better stress this, i dont want my words to be missunderstood by the less expert readers:

telbivudine is not a first line drug for hbv and is also out of guidelines in many countries  since it doesn t work on hbv due to high resistance rates.

the only antivirals safe for hbv are tenofovir and entecavir (not equal entecavir is weaker, it has resistance althogh very low 2% and no effect on hbsag like tenofovir).tenofovir 0% resistance and hbsag clearance on hbeag+

by the post i ment the combo tenofovir plus telbivudine can be safely used for those with kidneys problems.tenofovir will protect from resistance of any kind and telbivudine will improve kidneys function

[Paderla Anitha, DNB]

Hi, thanks for sharing. The available data suggest that telbivudine is slightly more effective than lamivudine in suppressing HBV DNA in patients who are HBeAg positive but the benefit does not appear to translate into a clinically important advantage for HBeAg seroconversion or histologic improvement. Regards.