Associations Between Hepatitis B Virus Genotype and Mutants and the Risk of HCC

[cam4930]

It seems that pre-core mutant reduces HCC risks, but BCP mutant increases HCC risks. The worst combination is:

genotype C + precore 1896 wild type + BCP 1762/1764 mutant

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http://jnci.oxfordjournals.org/content/100/16/1134.short

Results A total of 153 HCC cases occurred during 33 847 person-years of follow-up. The HCC incidence rates per 100 000 person-years for participants infected with HBV genotype B or C were 305.6 (95% confidence interval [CI] = 236.9 to 388.1) and 785.8 (95% CI = 626.8 to 972.9), respectively. Among participants with a baseline HBV DNA level of at least 104 copies/mL, HCC incidence per 100 000 person-years was higher for those with the precore G1896 (wild-type) variant than for those with the G1896A variant (955.5 [95% CI = 749.0 to 1201.4] vs 269.4 [95% CI = 172.6 to 400.9]) and for those with the BCP A1762T/G1764A double mutant than for those with BCP A1762/G1764 (wild-type) variant (1149.2 [95% CI = 872.6 to 1485.6] vs 358.7 [95% CI = 255.1 to 490.4]). The multivariable-adjusted hazard ratio of developing HCC was 1.76 (95% CI = 1.19 to 2.61) for genotype C vs genotype B, 0.34 (95% CI = 0.21 to 0.57) for precore G1896A vs wild type, and 1.73 (95% CI = 1.13 to 2.67) for BCP A1762T/G1764A vs wild type. Risk was highest among participants infected with genotype C HBV and wild type for the precore 1896 variant and mutant for the BCP 1762/1764 variant (adjusted hazard ratio = 2.99, 95% CI = 1.57 to 5.70, P < .001).

Conclusions HBV genotype C and specific alleles of BCP and precore were associated with risk of HCC. These associations were independent of serum HBV DNA level.

[stef2011]

no some hbvdna is needed in the blood, usually the mutants hide in the liver cells, but consider that if he/she got und by tenofovir it is almost impossible to have a resistance on tenofovir, never happened on hbv

a biopsy can detect all mutation registered in cccdna but it has been noted that after years of tenofovir the lamivudine mutants were cancelled from cccdna (the master template of virus) and that lamivudine could be used effectively again, maybe the same thing can happen after years of tnf on etv too

in italy only hospitals and universities were research on hbv is made have all these tests, in normal hospital it is available only the resistance tests for antivirals

they are complitely different tests architect is not ofr those tests.if you want those tests you have to look for research centers.germany, italy, hongkong and maybe france and spain are the most advnced to make these tests available to public too

[vijik]

yes i'm also looking for the machines they using for testing mutations resistance genotype. because it would be helpful when visiting lab for those tests. lab professionals seems to be lack of knowledge about there tests.

[chanthou]

If a person takes ETV and becomes resistant to it, then he switches to Tenofovir and becomes HBV undetectable, can he test for ETV resistant?

In other words, if a person is undetectable, can he test for mutant strains?  The machine can detect it?

[cam4930]

how to get tested the geno type, precore and bcp mutants? would abbott architect help to get tested?

There is a specific test that tests genotype, mutant, and drug resistance.

[cam4930]

This research only compared genotype B and C.

[vijik]

how to get tested the geno type, precore and bcp mutants? would abbott architect help to get tested?

[stef2011]

bad thing is they are the most common forms worldwide and tests are not comercially available
i had them all but genotype D and precore 1899 instead of 1896 plus q215Q and q215S, all linked to both cirrhosis and HCC.if these tests were available when my liver was still ok between 2002 and 2005 i would have been able to treat infection earlier, this is to say research is giving good results but tests are not available for all and most doctors are not aware of these data