Chronic Hep-B still active after 5 years

[shahzadsaahil]

I am a patient of Chronic Hepatitis B. I have been suffering from this disease since January 2009. I am constantly following up my disease since its diagnosis. I have undergone through a pegasys injection + Hepsera Tab therapy for one year from May 2009 to April 2010. I have taken Entacavir 0.5 mg  from May 2010 to October 2013. and i have been taking oral anti viral tenofo-B from November 2013 to April 2015 and in May 2015 Doctor prescribed me to start centaurus (Entecaver) in addition with Tenofo-B. My Medical history includes HBV DNA by PCR Quantitative is under 10 IU/ml after 5 Years. But HBeAg is still Reactive 27.09 and Anti-HBe is Non-Reactive 3.3. My ALT is 32. My RBC is 4.5 * 10^12/l, My Hb is 13.8, My Platelet Count is 215 * 10^9/l.

[pong58]

What is your alt level before starting antiviral in 2009?

[shahzadsaahil]

My Pegasys+Hepsera treatment was started in May 2009. March 2009 results are pre treatment results.

During my Pegasys+Hepsera treatment. My HBV DNA PCR Quantitative Results were:

March 2009   - 76200000 iu/ml
August 2009  - 1790000000 iu/ml
October 2009 - 1270000 iu/ml
January 2010 - 334000 iu/ml
April 2010      - 179000 iu/ml

During my Pegasys+Hepsera treatment. My HBeAg Results were:

March 2009   - 511.68
August 2009  - 309.73
October 2009 - 608.9
January 2010 - 528.6
April 2010      - 412

During my Pegasys+Hepsera treatment. My Anti-HBe Results were:

March 2009   - 16.21
August 2009  - 19.42
October 2009 - 15.48
January 2010 - 27.82
April 2010      - 20.03

Pegasys Treatment of 48 weeks ended in April 2010.

My Doctor prescribed me to start Entecavir 0.5mg daily after the end of Pegasys and Hepsera treatment after examining lab reports.

My Entecavir 0.5mg treatment was started in May 2010.  The results during this treatment are as under

August 2010     - 56500 iu/ml
November 2010 - 72800 iu/ml
February 2011   - 66000 iu/ml
September 2011 - 18600 iu/ml
April 2012          - 1059 iu/ml
October 2012     - 739 iu/ml
October 2013     - 166 iu/ml

During my Entecavir treatment. My HBeAg Results were:

August 2010     - 457
November 2010 - 508
February 2011   - 558.6
September 2011 - 202.3
April 2012          - 152.3
October 2012     - 74.45
October 2013     - 65.06

During my Entecavir treatment. My Anti-HBe Results were:


August 2010     - 18.68
November 2010 - 24.69
February 2011   - 37.39
September 2011 - 11.68
April 2012          - 6.57
October 2012     - 4.46
October 2013     - 4.68

My Entecavir Treatment of 3.5 years ended in October 2013.

Then my doctor prescribed me to start Tenofo-B 300mg daily after examining lab reports.

My Tenofo B 300 mg treatment was started in November 2013.  The results during this treatment are as under

May 2014      - 34 iu/ml
October 2014 - 10 iu/ml
May 2015      - 10 iu/ml

During my Tenofo B treatment. My HBeAg Results were:

May 2014      - 61.25
October 2014 - 41.8
May 2015      - 27.09

During my Tenofo B treatment. My Anti-HBe Results were:

May 2014      - 5.39
October 2014 - 3.99
May 2015      - 3.3

I am still under Tenofo B treatment but my doctor added up Entecavir 0.5mg once again in my recent visit. He asked me to follow up after three months.

This is my complete history, Hope you could understand.

[fighter_fighter]

your treatment is quite a mess why is it like that? can you post more detailed history?