Until now, I did not see guide for naive patients chronic hepatitis B treated with entecavir plus tenofovir.
I just know that if patients are resistant to adefovir may be replaced by teonofovir combined with entecavir under the guidance of EASL.
Indications and combinations tried current for various HBV populations.
For HBeAg-positive chronic HBV:
Interferon + lamivudine
Interferon + telbivudine
Interferon + ribavirin
Interferon + thymosin
Lamivudine + adefovir
Lamivudine + telbivudine
Lamivudine + thymosin
Lamivudine + HBV vaccine
Tenofovir + emtricitabine
Adefovir + emtricitabine
Clevudine + emtricitabine
Adefovir + bicyclol
Thymosin + bicyclol
For HBeAg-negative chronic HBV :
Interferon + lamivudine
Interferon + adefovir
Interferon + ribavirin
Clevudine + emtricitabine
Lamivudine + HBV vaccine
For HBV and HIV coinfection :
Interferon + adefovir
Tenofovir + lamivudine
Tenofovir + emtricitabine
Lamivudine + entecavir
For HBV and hepatitis C coinfection:
Interferon + ribavirin
Interferon + lamivudine
For Interferon non-responders:
Interferon + lamivudine
Interferon + GM-CSF
Interferon + HBV vaccine
For Lamivudine-resistant HBV:
Peginterferon + adefovir
Adefovir + lamivudine
Adefovir + entecavir (case reports)
Adefovir + tenofovir (case reports)
Tenofovir + lamivudine (case reports)
For Adefovir non-responders:
Adefovir + lamivudine
Tenofovir + lamivudine
Tenofovir + emtricitabine
For Pediatric population:
Lamivudine + interferon-α
For Acute HBV infection:
Adefovir + lamivudine
For Severe HBV reactivation:
Nucleosides + steroids
For Asymptomatic chronic carriers:
Lamivudine + HBV vaccine
Prevent recurrence after liver transplantation in HBV-positive recipients:
Lamivudine + HBIG
Adefovir + HBIG
Entecavir + HBIG
Lamivudine + adefovir
Prevent recurrence after liver transplantation with HBcAb-positive donor:
Lamivudine + HBIG