Aa
Correct me If I'm wrong...
Tenofovir and Entecarvir only stop or reverse liver damage. Yes, it could help you get undetectable HBV DNA, but it also worsen your liver cells' infection? Does that even make sense? Because they inhibit HBV from growing, should they lower your virus load, then your liver should become less infected, and have time to repair itself?
Alinia seems promising at dose 2g/day for HBeAg negative. What about HBeAg positive patient with undetectable HBV DNA already on Tenofovir or Entecarvir therapy? Would its combo work as well?
Anybody research on simvastatin yet? Simvastatin lower cholesterol, but also affect HBV, because HBV use cholesterol to replicate? I've read the prescription for Simvastatin said that one should be careful to use it if there is active liver disease. IF HBV DNA undetectable, ultrasound normal, blood work normal would be considered active on liver disease?
I've been undetectable HBV DNA for 2 years now, ultrasound normal, AFP, Fibroscan F0, Creatinin normal, HBeAg positive, HBsAg (Abbott Architect) >1500 IU. Should I try Alinia or Simvastatin, or Peg-Intron to get a chance o clearing HBV?
@stef2011
Thanks
Alinia seems promising at dose 2g/day for HBeAg negative. What about HBeAg positive patient with undetectable HBV DNA already on Tenofovir or Entecarvir therapy? Would its combo work as well?
Anybody research on simvastatin yet? Simvastatin lower cholesterol, but also affect HBV, because HBV use cholesterol to replicate? I've read the prescription for Simvastatin said that one should be careful to use it if there is active liver disease. IF HBV DNA undetectable, ultrasound normal, blood work normal would be considered active on liver disease?
I've been undetectable HBV DNA for 2 years now, ultrasound normal, AFP, Fibroscan F0, Creatinin normal, HBeAg positive, HBsAg (Abbott Architect) >1500 IU. Should I try Alinia or Simvastatin, or Peg-Intron to get a chance o clearing HBV?
@stef2011
Thanks
Tenofovir and Entecarvir only stop or reverse liver damage. Yes, it could help you get undetectable HBV DNA, but it also worsen your liver cells' infection?
yes correct.in case of no liver damage they might be useful to weaken the virus together with immune modulators.hbvdna has a immune suppressive effect like hbsag and hbeag, the strongest effect of immune suppression is made by hbsag, no hbsag no hbv infection from replicor trials
Does that even make sense? Because they inhibit HBV from growing, should they lower your virus load, then your liver should become less infected, and have time to repair itself?
as ais previously hbvdna is a poor test that reflects virus replication only, no virions.hbvdna und doesnt mean there is no virus and no replication
the number of infected cells is made by cccdna quant, which is mainly the integrated hbv in human dna.hbsag can reflect part of infected cells and immune response since only immune system can lower hbsag (and of course immune modulators but little effect)
liver should become less infected, and have time to repair itself?
no because even without virions cccdna inside cells keeps multipling as cells multiply.so from one cell with cccdna you can get many other as the cells multiply
Alinia seems promising at dose 2g/day for HBeAg negative. What about HBeAg positive patient with undetectable HBV DNA already on Tenofovir or Entecarvir therapy? Would its combo work as well?
too early to say but for now the same patterns of interferon seems to apply to ntz.of course when ntz lowers hbsag is incredibly faster than everage interferon effect
those with faster results are inactive carriers with hbvdna und and hbeag neg, low hbsag, those with an active immune response in the end
Anybody research on simvastatin yet? Simvastatin lower cholesterol, but also affect HBV, because HBV use cholesterol to replicate?
i am trying liposomal gsh which lowers intracellular cholesterol, the most effect on virus replication comes fro m lowering intracell chol.the active antiviral doses are too high, about 3500 lipo gsh per day, too expensive.for now i am just using it for chol, we will see hbsag the 26th of may but i am about to start gcmaf so it would be difficult to judge lipo gsh, in any case it is more potent than sim but no sides at any dose, only expensive...
HBsAg (Abbott Architect) >1500 IU. Should I try Alinia or Simvastatin, or Peg-Intron to get a chance o clearing HBV?
definitely yes but i'd wait to see what gcmaf does but alinia+interferon should be the most potent combo if you are out of any drug
yes correct.in case of no liver damage they might be useful to weaken the virus together with immune modulators.hbvdna has a immune suppressive effect like hbsag and hbeag, the strongest effect of immune suppression is made by hbsag, no hbsag no hbv infection from replicor trials
Does that even make sense? Because they inhibit HBV from growing, should they lower your virus load, then your liver should become less infected, and have time to repair itself?
as ais previously hbvdna is a poor test that reflects virus replication only, no virions.hbvdna und doesnt mean there is no virus and no replication
the number of infected cells is made by cccdna quant, which is mainly the integrated hbv in human dna.hbsag can reflect part of infected cells and immune response since only immune system can lower hbsag (and of course immune modulators but little effect)
liver should become less infected, and have time to repair itself?
no because even without virions cccdna inside cells keeps multipling as cells multiply.so from one cell with cccdna you can get many other as the cells multiply
Alinia seems promising at dose 2g/day for HBeAg negative. What about HBeAg positive patient with undetectable HBV DNA already on Tenofovir or Entecarvir therapy? Would its combo work as well?
too early to say but for now the same patterns of interferon seems to apply to ntz.of course when ntz lowers hbsag is incredibly faster than everage interferon effect
those with faster results are inactive carriers with hbvdna und and hbeag neg, low hbsag, those with an active immune response in the end
Anybody research on simvastatin yet? Simvastatin lower cholesterol, but also affect HBV, because HBV use cholesterol to replicate?
i am trying liposomal gsh which lowers intracellular cholesterol, the most effect on virus replication comes fro m lowering intracell chol.the active antiviral doses are too high, about 3500 lipo gsh per day, too expensive.for now i am just using it for chol, we will see hbsag the 26th of may but i am about to start gcmaf so it would be difficult to judge lipo gsh, in any case it is more potent than sim but no sides at any dose, only expensive...
HBsAg (Abbott Architect) >1500 IU. Should I try Alinia or Simvastatin, or Peg-Intron to get a chance o clearing HBV?
definitely yes but i'd wait to see what gcmaf does but alinia+interferon should be the most potent combo if you are out of any drug
hbv virus is integretated in human dna and hbvdna is not the hbv virus and not the number of virions around
hbvdna is a useless test to see number of infected cells, it is only used to measure the effect of antivirals
hbsag,cccdna, pgrna are the tests that can reflect infected cells, also ratio of hbsag/hbvdna might be useful to reflect number of virions
hbvdna test is mainly made to support the use of antivirals, only US, canada, uk are still lacking all the other tests, europe, indian, china, vietnam all have hbsag quant.they are also lacking fibroscans, this just reflects the markets, not patients heath or scinece
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