Discontinue Lamivudine ?

[Docpch]

Hello everyone, this is my first post . Have been following every activity on the forum for a while.
HBV sufferer since birth from vertical transmission .
On Lam since  1998 till present, Adefovir added to Lam 2005 and replaced with Tenofovir in 2008 so at present  on Lam / Tenofovir.
August 2010 doctor ( same doctor for 30 years) discontinued both( Lam and TDF) and in December 2010 had a near fatal Virological  and Biochem. breakthrough and both Lam and TDF were restarted.
As of 2007 resistant mutants: L180M, M204V&I, A181V, N236T. Some of them unlike the wild type are proven to be cytotoxic (via apoptosis).
HBsAg:  in Dec/2010 52.02, Jan/20111 31.59 and Oct/2011 >250.00 , Why increasing? Antivirals suppressing immune response? Units?(doctor wouldn't say)
Genotype unknown, doctor says probably D.
Fibroscan Oct/2011 - 8.1kPa
DNA at present undetectable
ALT / AST 24/22 U/L at present
Ultrasound and Biopsy show Diffusely fatty liver.
November 2011 for first time HBeAg-ve and Anti-HBeAg still -ve ,  is it because of natural progression? Antivirals? or precore and/or CP mutants?
Read a study that Tenofovir has a potential to develop resistance to N236T and A181T/V.
So my question is, given the history of long term use of Lamivudine and  creation of "bad" mutants with possibility for phenotypic, mutant caused flareup , is it safe to discontinue Lam and continue TDF only as monotherapy?
Any and all responses will be sincerely appreciated , no comment will be slighted
Thank you all,

studyforhope, Stef2011, StephenCastlecrag?

[stef2011]

after using lam you can only use tenofovir or interferon, no other drugs

possibly check the mutants, lam can make virus cytopatic, it means hbv can destroy your liver even with no replication hbvdna undetactable and normal alt

it makes all types of mutants, even those that makes vaccines ineffective so all people around you is at danger and can t be protected
this type of vaccine escape mutant can make hbv not curable because also hbsab antibodies wont work

if i get a doctor to prescribe me lam today i'd sue him immediately in my country and if i could not sue him i d destroy his life like he did with mine

[stef2011]

after making hbvdna undetactable by tenofovir or entecavir interferon works differently

we do know what to do with the numbers, your doctor is pretty stupid the lower is of course the better, no need to really know it just needs to go down

Should I expect complications if discontinue Lam and carry on with TDF only as mono.
if you go on with lam mono you can count of dying for sure according to the mutants developped.....tdf has no mutants and no such complications

[Docpch]

Tried IFN 6years ago but coudn't take it for more than 2 months because of sides. Probably will be unsuccessful again.
Doctor does not wish to have HBsAg quantity because "we wouldn't know what to do with the numbers" .
Should I expect complications if discontinue Lam and carry on with TDF only as mono.
Also intentd to start growing my own Aronia berries as a dietary supplement for the fatty liver with lots of lemons in combination with Ursodeoxycholic acid. Will report on the progress.
Thanks

[Docpch]

Did you get tested for mutants and resistance. If you did which mutants did you get.
Thanks

[stef2011]

add interferon to tenofovir+lam+alinia if hbvdna is undetactable from long time

make a diet for fatty liver, see my post "update on my fatty liver" and copy what i did

hbsag wont decrease on tdf and lam because these antivirals are useless on hbsag-if you add inteferon+alinia to tdf+lam hbsag should deacrease, you need to monitor hbsag quantity to know if this combo works

at the moment your tests are not hbsag quantitative, the must make diluition of your blood sample to get the exact number of hbsag, a result like >250iu/ml is useless

[chanthou]

I combine tenofovir and entecavir for two months and then go with tenofovir alone. Have been undetectable for 2 years.