Effect of artemisinin/artesunate as inhibitors of hepatitis B

[stef2011]

http://www.ncbi.nlm.nih.gov/pubmed/16122816

http://www.ncbi.nlm.nih.gov/pubmed/18699744

http://cid.oxfordjournals.org/content/47/6/804.full

i found artesunate is used by many patients for other viruses since it has braod antiviral specturm, i will check with them safe doses (should be same as for malaria treatment) and experienced sides.
alt/ast must be stricly tested weekly or monthly to detect any liver damage for those with normal alt/ast and this compound must be avoided in case of severe liver damage/fibrosis/cirrhosis

[stef2011]

actually its the immune system to blame to peginterferon response, i dont know artesunate well but this is common side effect of peg

i think you are having a big response, it is not always true that the worst symptoms equal hbsag decline/clearance but if it is ok with your doctor keep this combo.

remember to take paracetamol at least 1hr before the injection, this was guidelines we received at my hospital since fever is bad on start of therapy, if you are not taking paracetamol the nausea/vomit may be due to the fever

what does doctor say about it?

you are close to the 12 weeks point then hbsag will tell us if you are having a good response and probability of hbsag clearance end of therapy

[Jatashankar]

I am taking artesunate 200mg tab twice daily (400mg/day) from last  22 days along with peginterferon for hbv. Yesterday after 2 days of my 8th inj of IFN I had high grade fever and 1episode of vomiting after which fever disappeared. Now this was the first vomit I had during IFN therapy but previously also 2-3 times I felt vomit but subsided.
The question is which drug to blame IFN or artesunate. I am also taking nitazoxanide and tenofovir.
My sgpt and sgot gradually rose to 95iu/ml during IFN therapy till date.  Again whom to blame artesunate or IFN?

[80percenthidebrain]

A team that create sovosbufir or sovaldi now create a cure drugs for hbv using npv018 and i bet it will success as the creator is the philadelpia research team that create sovaldi... but the sad thing is it will going to phase 1 on 2015... it will be very long way to establish in market

[veteranB]

http://www.biocentury.com/products/nvp018

http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0081783

[veteranB]

Are you saying that  nvp018 is artemisinin?

There are reports that people infected with malaria thatvwere treated for it also have lost hbsag.

[80percenthidebrain]

It have been in phase 3 in europe.. it mean that if big pharma also have give fund of 150 m dollar it should be establish in a soonest date right ???? I hope and really hope... veteran, do you have any info ?