I searched the web to find the latest on REP 9AC' which is a hope of good life for all of HEP carriers and here the info..
"Company REPLICor
Tags Trial Results, Phase II, Systemic Anti-Infectives
Date September 25, 2012
Montreal, Quebec – Tuesday , September 25, 2012 – REPLICor is currently undertaking a proof of concept trial in patients with chronic hepatitis B (HBV) undergoing treatment with its nucleic acid polymer (NAP) REP 9AC’ in combination with Zadaxin™ or Pegasys™. The hepatitis B surface antigen protein (HBsAg) is produced in large excess by the HBV infection as subviral particles (SVPs) which act to block the immune response to HBV infection. NAPs act to block the release of SVPs from infected hepatocytes, providing an effective method for clearing HBsAg from the blood. The elimination of HBsAg in the blood of HBV-infected patients is well known to be the best indicator of a curative response to treatment.
Interim results from REPLICor’s proof of concept trial were disclosed today at the 2012 held at the University of Oxford Christ Church and Examination Schools, Oxford, England. Patients who had cleared HBsAg from their blood with REP 9AC’ monotherapy were subjected to combination treatment with REP 9AC’ and either Pegasys™ or Zadaxin™.
Profound increases in anti-HBV antibodies or immune function were observed in all patients with as few as 6-10 weeks of combination treatment. Many patients have achieved HBV antibody levels seen in healthy patients after vaccination with a total of 12 weeks of combination treatment. All patients who have achieved this therapeutic vaccine-like response have been removed from treatment and continue to control their viral infections off treatment. The remainder of patients are expected to achieve full immunological control of their infection in the coming weeks. REPLICor expects that the profound reactivation of a therapeutically effective immune response with short term Zadaxin™ or Pegasys™ treatment given in combination with its HBsAg release inhibitor REP 9AC’ can achieve durable immunological in most patients, regardless of viral genotype or state of their HBV infection"
Please let me know if any one has any latest information then this one...I am praying god every min of the day to help all of us...to comeout of this truma..
.I started with Hbeag negative and undectable VL in 2006 but suddendly VL become 3286iu/ml in 2012. Does this mean i have mutant HEBAG? do to which VL is replicating ? Please advise
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Moreover I have completed 3 weeks of Baraclude .5mg daily once and now some I can see relieft in my abdominal pain and no flares. Is it possible with 3 months of regularly having Tab Baraclude we can see a good improvement and chance of clearing HBSAG to negative..
I started with Hbeag negative and undectable VL in 2006 but suddendly VL become 3286iu/ml in 2012. Does this mean i have mutant HEBAG? do to which VL is replicating ? Please advise
its 2 weeks now i have started Baraclude .5mg and the pain in my liver part is not reduced and moreover i am totally depressed and unable to eat food..always out of mood and feeling like left alone in the world.
I am totally worried and i am getting actue flare from my liver part...unable to change mood..
Please advise what should i do to live normally along with this symptoms..
Pain in the abdomen, cld also be some immune activity, trying to react to clear infected cells .
Do you mean its good..it will help and clear HDV from infected Cells ??/
Doc prescribed to Baraclude Entv.5mg and i am takeing it from past 10 days...pain reduced however slight burning sensation and discomfort still presist..
Thanks
Pain in the abdomen, cld also be some immune activity, trying to react to clear infected cells