Aa
full hbv genome sequence at policlinico torvergata rome
full hbv genome sequence available at policlinico tor vergata "rome", this is the full hbv genome, not just hbsag or known mutations.this s not done by commercial kits, i will be making the test on 18 nov
i also have hbsag quant at this hospital because they get results by about 2 days, results are delivered online
http://www.ptvonline.it/uo_viromolecolare.asp
http://www.ptvonline.it/file_allegati/hbv.pdf
as to hcc risk, it only lowers by nucs but hcc develops even under nucs.i think the main reasons for HCC can be abnormal nagalase 100% and oxdative stress
that's ignorance you can t check when tx fails you have to check before.......if i was to follow your ignorant doctor i'd have so many mutants now that any nuc would fail
rtq215s is not directly lam and adv mutation but it makes no response so that lam and adv mut arise
also the genotype is very very important because:
a and d have fast response on nucs to clear hbsag and hbeag although on few
b and c, especially c, has very high risk for HCC
d has very little response on interferon
what can we say about your doctor?useless ignorant just pushing nucs market.i wounder if many of these doctors have some gifts from drug makers....they are not making patients helath better at all with this ignorance or way of acting
rtq215s is not directly lam and adv mutation but it makes no response so that lam and adv mut arise
also the genotype is very very important because:
a and d have fast response on nucs to clear hbsag and hbeag although on few
b and c, especially c, has very high risk for HCC
d has very little response on interferon
what can we say about your doctor?useless ignorant just pushing nucs market.i wounder if many of these doctors have some gifts from drug makers....they are not making patients helath better at all with this ignorance or way of acting
Thanks for the info. PLease keep us posted.
It makes sense that you make all of these test before starting tx to maximize the response of the tx. It's a pity that many of us do not have access to these types of tests and surprisingly many doctors (liver specialists) do not know about them. Like my doctor who told me that mutations tests are for those who don't respond to the tx. And I don't need genotype test also because since I am hbsag+ I have automatically 200% higher risk than others without hbv to have hcc. So, it doesn't really matter whatever genotype it is. I don't know whether she's being straight forward or totally emotionless as they are seeing so many patients a day. Sometimes it can be really depressing to see doctors.
It makes sense that you make all of these test before starting tx to maximize the response of the tx. It's a pity that many of us do not have access to these types of tests and surprisingly many doctors (liver specialists) do not know about them. Like my doctor who told me that mutations tests are for those who don't respond to the tx. And I don't need genotype test also because since I am hbsag+ I have automatically 200% higher risk than others without hbv to have hcc. So, it doesn't really matter whatever genotype it is. I don't know whether she's being straight forward or totally emotionless as they are seeing so many patients a day. Sometimes it can be really depressing to see doctors.
forgot to mention the main reason for me to have the full genome of my hbv:
i ahev the resistance secondary mutation rtq215q/s even if never treated (naive treatment), it is thought that this mutation carries other mutations with it and the test used in pisa is not potent enough to detect them all.when i did the test i was already hbvdna 50iu/ml and commercial tests cant detect all mutations with hbvdna very low
rtq215s is a secondary mutation with decrease response to lam, adv and possibly in vitro tnf too.researcher said that sometimes this mutation has decreased response on nucs.so i do need to have this test performed so that if a combo is needed i have the data that requires that.alinia and simvastatin that i am using now should be able to suppress mutants if there are any, but this is only theoric, while etv+tnf will make me very safe
in the lucky case i have only q215s mutant i will avoid etv+tnf combo and possible sides effect over a long term use
i dont know yet what they use but probably once of the most potent tests because they dont need hbvdna detactable for the test to find the mutants
What would be the advantage for those who make the test?
almost none if a researcher is not available to see results with the patient.but as research goes on it may be very important to have this test if on antivirals
the test is able to detect possible resistance to the antiviral and rate of mutations during antiviral therapy so tht another antivirals is added much before any clinical sign develops
Do people from other countries have to come to Rome to make this test if they are willing to pay?
definitely yes and ask by email in advance if such service can be available to them and if booking an appointment is necessary
according to the study i saw some of these researchers maybe able to see if antiviral is going to clear hbv or going to make resistance mutations
almost none if a researcher is not available to see results with the patient.but as research goes on it may be very important to have this test if on antivirals
the test is able to detect possible resistance to the antiviral and rate of mutations during antiviral therapy so tht another antivirals is added much before any clinical sign develops
Do people from other countries have to come to Rome to make this test if they are willing to pay?
definitely yes and ask by email in advance if such service can be available to them and if booking an appointment is necessary
according to the study i saw some of these researchers maybe able to see if antiviral is going to clear hbv or going to make resistance mutations
What kind of test is "full hbv genome sequence"?
the virus even when hbvdna und by antivirlas keeps making mutations to adapt to the antivirals.we just know the mutations that make antiviral resistace but there are many many others, by this test you see them all even if unknown
the same hospital just made a study on quasispieces during entecavir therapy, those without mutants in the hbsag region adapting to ntecavir are those who cleared hbsag......so even if most mutants are unknown it is good to know them and as research goes on to aquire new info
in my case we want to see how many mutants are present and if a combo etv+tnf is suggested
the virus even when hbvdna und by antivirlas keeps making mutations to adapt to the antivirals.we just know the mutations that make antiviral resistace but there are many many others, by this test you see them all even if unknown
the same hospital just made a study on quasispieces during entecavir therapy, those without mutants in the hbsag region adapting to ntecavir are those who cleared hbsag......so even if most mutants are unknown it is good to know them and as research goes on to aquire new info
in my case we want to see how many mutants are present and if a combo etv+tnf is suggested
What kind of test is "full hbv genome sequence"?
What would be the advantage for those who make the test?
Do people from other countries have to come to Rome to make this test if they are willing to pay? or the blood have to be sent by courier service?
Sorry..so many questions..
web site is in italian language....
What would be the advantage for those who make the test?
Do people from other countries have to come to Rome to make this test if they are willing to pay? or the blood have to be sent by courier service?
Sorry..so many questions..
web site is in italian language....
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