HBV almost cleared 12 weeks with interferon+simvastatin

[Otan]

Below is my experience with Interferron teraphy,
At 1st injection, Doctor asked me to stay at hospital for 24 hrs to see the effect, but everything felt normal. Same thing happen with 2nd injection.
After 3rd injection, started feel flu symptons , dry mouth (thirsty), less taste for food (my portion still normal) but still feel strong
After 4th injection, feel headache, sleepy/weak, less taste for food  and itching. But I still can riding bicycle for exercise.
After 10th injection, sometime light headache, dry mouth,  itching , less taste for food  but feel little stronger.

Below is the Lab test history, after dose#12 HBV DNA not detected.

                        Base line 1st dose 4th dose         8th dose         12th dose                Ref. Range   Unit
Date:      13-Sep-11 20-Oct-11 21-Oct-11 11-Nov-11 16-Nov-11 09-Dec-11 15-Dec-11 06-Jan-12 11-Jan-12
AST (SGOT)                    35*                             49*            63*                     67* <33            IU/L
ALT (SGPT)                    63*                             78*             89*             90* <50           IU/L

HBsAg        366.44* 255.68*                                                   176.4* <0.05 IU/mL

HBV-DNA     2.54 x 10^5 2.54 x 10^5                                 no detectd         

Thanks.  

[stef2011]

remember not to stop interferon until hbsag is negative, you should nt need 48 weeks to clear it but if hbsag is still detactable you should not stop it until it is clered

full protection and immunity happens when hbsab rise to good levels like qt least 250miu/ml, sometimes interferon alone is not able to make hbsab in that case when hbsag is negative hbv vaccine is used with immune henancers

[Otan]

"did you started simvastatin before interferon treatment or together? "
Not before, They started together.

"you can increase sim to 20mg too if you have had no sides from it"
No sides from sim. Doctor stop sim when He found chol become in range then change to Lipanthyl 100 to effect something else I am not very sure. But doctor ask me to eat less sweet food, reduce carbo.

"the sides you experienced with interferon are signs of immune activation"
I wish I get this gift soon...

FYI, before and during interferron, As much as I can I avoid oily food (only steamed food), eat fruits. May be this help also.

[Otan]

"remember not to stop interferon until hbsag is negative, you should nt need 48 weeks to clear it but if hbsag is still detactable you should not stop it until it is clered "
I will not. Thanks God if this less than 48 since this is an expensive cost 210 usd/injection/week

[glai123]

is it possible that upon detection of hepa b, i can still be negative from it thru medication? how long? 09152054994 pls help..thnks

[stef2011]

Doctor stop sim when He found chol become in range then change to Lipanthyl 100 to effect something else I am not very sure. But doctor ask me to eat less sweet food, reduce carbo.

very wrong choice, sim has antiviral effect on hbv you shold start it again

But doctor ask me to eat less sweet food, reduce carbo.

this is very correct

[stef2011]

Cholesterol Drug Statin May Improve Standard Hep C Treatment Efficacy
http://www.hepmag.com/articles/hcv_fluvastatin_statin_2501_20219.shtml

Simvastatin potentiates the anti-hepatitis B virus activity of FDA-approved nucleoside analogue inhibitors in vitro
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2869246/

of course your doctor has no idea sim has antiviral effect on hbv in combo with antivirals and interferon and was thinking about cholesterol levels only but that s a bit of ignorance on hbv.chol is upregulated by hbv, it is not due to you or to food, and hbv upregulates chol because that's needed to make hbsag
interferon works lowering chol inside the cells so that hbv has no way to make hbsag, sim lowers chol in blood and helps weaken hbv