HEP B Virus

[Bee55]

if both partners have HEP B and no antibody, and/or one have antibody AND mutated HEP B, can unprotected sex increase viral count in both, and does that increase damage to the liver?

[stef2011]

but not sharing the bathroom?
yes it just us because of the transplant to avoid any possible contamination from hbv or other patogens

did she have active infection?maybe she cleared both wild type and mutant

these tests are available only at research centers, i have the mutant profile by blood test at an int'l research center in italy but resistant test to NUc drugs and precore/BCP test are commercially available everywhere although if hospital wants to save money on people's health they don t use it

infection with moderate hbvdna level: blood sex, very high hbvdna saliva, blood, sex, hbvdna und, blood

infection with mixed genotypes is much more aggressive, usually genotypes are the same in the same geografic area.as to the mutants i know about mine q215s which is quite common on genotype D, higher alt, more cirrhosis cases

there is also E,F,G, H but very very rare and in very small areas in the world

the only thing that matters clinically is fibrosis grade and among fibrosis only f3 and f4, f1-f2 has no meaning it is just artificial grading by observation but no clinical meaning, F1 and f2 are very mild fibrosis, there is also a grade for inflammation which is higher than fibrosis it is not important at all if fibrosis is little

you can also check all posts about antifibrotic food and use it in your diet to regress the little you have and prevent liver cancer

[Bee55]

Wow, thanks, you are very knowledgeable. Appreciate you taking the time. May I ask if you and your sister were contracted the virus through the birth canal due your mom having the wild type at the time?
exactly just how easy to get the HEP B virus? (not sharing same bathroom?) So far we were told, that it is blood to blood contact and sexual intercourse only, and what understood, significant amount of blood to blood (open sore). Also, that kissing alone is not enough saliva to get it.
So what you are saying is, that if my fiance has the A...B..C..D (is there more?) if I have only his genotype, and did not make my own, or even if I did make my own, but made the same genotype, than the virus is not any stronger to do more damage as we passing it back and forth through sexual contact?
Do you happen to know, what "grade 2 level 1 liver damage" means? (it is on my needle biopsy report - per "Batts and Ludwig type testing") We tried to look it up, but found no reference.

[goofygoatboy]

bee55 and i are partners.  she is HBVsAb -, while i am hbvsAb + so it seems she may have both the wild type and the mutant i have. we have had plenty of unprotected intecourse so it seems likely we both have the same virus except maybe i am continuously clearing the wild type. i agree we have to get genotype and mutant tests but have not yet. do you know if commercial tests are readily available for this?  i haven't found them yet if they are.

...but not sharing the bathroom?  it seems extreme, is this just extra caution on your family's part? it's understandable after a liver transplant of course, i'm just asking.

btw, i found a report today of someone with similar profile to mine (except his genotype was known to be A) cleared the virus after 24 weeks of peg-ifn.  now i am wondering if he is suseptible to reinfection with immune escape variants.

[stef2011]

if you have exactly the same genotype it is no trouble at all generally but
if the replication is active you might exchange mutants in case you have many

you must find a good lab to check your genotype and mutants possibly with sensibility 5%, if both genotype and mutants or both wild type no risk to make hbv more aggressive

in my experience we have the same genotype in my family but different mutants:
my mother had wild type and after liver transplant of course cleared hbv from assays detactability
my sister has no liver damage at all better than normal population, fibroscan 4.4kpa (generally 5.0kpa), so they didn t check her mutants
me: A1762T-G1764A-G1899A-rtQ215Q/S-genotypeD, with rtq215q/s there are usully other mutants at low level
my father: cleared hbv

so in my family we do not share same bathroom with my mother and we take care about it