Hbs+ hbeag+ --- VL after tx...

[grmr]

Need some thoughts here…

As you may have read going through this thread I’m still Hbeag+ ALT slightly out og range (70-80) and my VL has always beein >100000000.

I had been on Pegasys IFN180 mono tx for 8 months (2 years ago) and then I quitted as I seemed to not responding to tx… (just for you info I have not had any side effect at all but VL was almost always >100000000).

After that I just have my blood tests done every 3 or 4 months, ultrasound every 6 months  …… so I’ll keep on monitoring how this stuff is progressing..

Now.. got my latest labs last week.. and I was really surprised as my VL dropped down to 50000000… yes mate I know this is still high but I’ve never had a result like this in 26years.. Neither had I while on tx…

ALT still around 70 however….

Any ideas?????

thanks to you all guys!!!

[stef2011]

of course my hbvdna and hbsag are much lower than yours because my immune system is much more active, but in my case hbv escaped most of my response

in ur case the chances of success with therapy are higher because you dont have a good immune response yet, so hbv has not mutated yet to escape it

so tdf will make hbvdna und and make some immune response

interferon will boost that little immune response to clear hbv

having hbvdna nd will make impossible for hbv to mutate and escape your response

[stef2011]

no vitamin d3 is protecting your liver from fibrosis and severe liver daamge as clearly shown by a poster at the liver meeting.the liver with vit d reached f1-f2 fibrosis while the others got advanced nodular cirrhosis

high cholesterol and platlets 190.000 are due to hbv, keep in mind that also cholesterol promotes fibrosis and liver damage, it is all linked with hbv and damage.making cholesterol lower you will also prevent fibrosis

by the way i also had tot chol 218 when i had  hbvdna 580.000iu/ml and alt 600, while it decreased to normal with hbvdna und

[grmr]

is that harmful? may it be caused by VIT d3 i'm currenlty intaking 10000 daily?

[stef2011]

sorry confused it because it should be 1.15

you can use biostatine, it is a red yeast rice supplement, it will ower cholesterol in about 20-30 days, this way you will weaken a little hbv and you will respond better to therapies.once you start therapy you can stop biostatine or lower it to one pill a day
biostatine can be found in farmacia, eroristeria, parafarmacie, it doens t need prescription.use that brand only because it is not sure all red yeast supplements work.i hve seen them at auchan and coop but dont know how reliable other brands are
if doctor agrees you may also use simvastatin with prescription but only updated doctors know use of sim is safe, so you using biostatine is easier

of course do not keep chol so high, there is an increased risk of arterosclerosis and chol related diseases in hbsag carriers because hbv upregulates genes

[grmr]

Pt was (protrombina). Platelettes are arounf 190

so should I worry for cholesterol?

[stef2011]

cholesterol is controlled by hbv, cholesterol genes are changed by hbv to make its antigens

re check platlets 115 is extremely low, lowest normal range is 150.if so low start tenofovir as soon as possible and l carnitine.low plt means a lot of damage is being done in the liver

if plt doesn t get in normal range and hbvdna gets low fast by 6 months do ask for tdf+etv combo and then interferon add on, jus tlike i am doing, tdf+etv are very fast to make hbvdna und by 6 months even when so high.interferon with low platlets is a problem